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The survival value of systematic lymphadenectomy for endometrial cancer is unclear and controversial
.
Recently, a domestic team conducted a related study to evaluate the long-term survival effect of combined pelvic and para-aortic lymphadenectomy on patients with early-stage endometrial clear cell carcinoma
The survival value of systematic lymphadenectomy for endometrial cancer is unclear and controversial
The study included patients with early-stage endometrial clear cell carcinoma who underwent surgical staging from 2012 to 2017 in three Chinese teaching hospitals
.
The clinicopathological characteristics of patients with and without systematic lymphadenectomy were compared between the two groups
The study included patients with early-stage endometrial clear cell carcinoma who underwent surgical staging from 2012 to 2017 in three Chinese teaching hospitals
Systematic lymphadenectomy was performed in 244 patients and no lymph node dissection was performed in 89 patients
The proportion of tumors of 2 cm and above in the two groups (48.
0%, 52.
9%, P=0.
755), LVSI (24.
2%, 21.
3%, P>0.
999), and positive peritoneal cytology (11.
9% and 10.
1%, P>0.
999)
.
In terms of surgical staging, the rate of laparoscopic surgery in the systematic lymph node dissection group was 68.
The proportion of tumors of 2 cm and above in the two groups (48.
In patients who did not undergo systematic lymphadenectomy, the most common recurrence was lymph node recurrence (15.
The 5-year disease-free survival rate of patients with systematic lymph node dissection was 64.
10%, and the 5-year disease-free survival rate of patients without lymph node dissection was 45.
05%
.
Patients who underwent systematic lymphadenectomy had better disease-free survival than those who did not (HR, 0.
The 5-year disease-free survival rate of patients with systematic lymph node dissection was 64.
The 5-year overall survival rate was 68.
87% (95% CI, 62.
33%-74.
51%) in the lymphadenectomy group and 53.
33% 53.
33% (95% CI, 41.
63) in patients without systematic lymphadenectomy %-63.
69%)
.
Patients who underwent systematic lymphadenectomy had better overall survival than those who did not (HR, 0.
The 5-year overall survival rate was 68.
87% (95% CI, 62.
33%-74.
51%) in the lymphadenectomy group and 53.
33% 53.
33% (95% CI, 41.
63) in patients without systematic lymphadenectomy %-63.
69%)
.
Patients who underwent systematic lymphadenectomy had better overall survival than those who did not (HR, 0.
58.
95% CI, 0.
39-0.
85.
P=0.
005)
.
The 5-year overall survival rate was 68.
87% (95% CI, 62.
33%-74.
51%) in the lymphadenectomy group and 53.
33% 53.
33% (95% CI, 41.
63) in patients without systematic lymphadenectomy %-63.
69%)
.
Patients who underwent systematic lymphadenectomy had better overall survival than those who did not (HR, 0.
58.
95% CI, 0.
39-0.
85.
P=0.
005)
.
Among patients undergoing systematic lymphadenectomy, survival analysis was performed by subclassification of the number of lymph nodes removed
.
Patients who had 10 to 20 or more regional lymph nodes removed had better DFS and OS than those who had less than 10 regional lymph nodes removed
.
.
Patients who had 10 to 20 or more regional lymph nodes removed had better DFS and OS than those who had less than 10 regional lymph nodes removed
.
Among patients undergoing systematic lymphadenectomy, survival analysis was performed by subclassification of the number of lymph nodes removed
.
Patients who had 10 to 20 or more regional lymph nodes removed had better DFS and OS than those who had less than 10 regional lymph nodes removed
.
After adjusting for relevant variables, systematic lymphadenectomy was still associated with improved DFS (aHR, 0.
57, 95%CI 0.
39-0.
85, P=0.
005) and OS (aHR, 0.
64, 95) in patients with early stage endometrial clear cell carcinoma %CI, 0.
41-0.
99, P=0.
047) were independently correlated
.
57, 95%CI 0.
39-0.
85, P=0.
005) and OS (aHR, 0.
64, 95) in patients with early stage endometrial clear cell carcinoma %CI, 0.
41-0.
99, P=0.
047) were independently correlated
.
After adjusting for relevant variables, systematic lymphadenectomy was still associated with improved DFS (aHR, 0.
57, 95%CI 0.
39-0.
85, P=0.
005) and OS (aHR, 0.
64, 95) in patients with early stage endometrial clear cell carcinoma %CI, 0.
41-0.
99, P=0.
047) were independently correlated
.
In conclusion, the study showed that patients with early-stage endometrial clear cell carcinoma who underwent systematic lymphadenectomy had better long-term survival than those who did not
.
.
Studies have shown that patients with early-stage endometrial clear cell carcinoma who underwent systematic lymphadenectomy had better long-term survival than those who did not
.
Studies have shown that patients with early-stage endometrial clear cell carcinoma who underwent systematic lymphadenectomy had better long-term survival than those who did not
.
Original source:
Original source:Tian Y, Ran L, Liu Y, Xu Y, Shen J, Mi Gs and Ke Fm (2022) Systematic Lymphadenectomy and Oncological Outcomes of Women With Apparent Early-Stage Clear Cell Carcinoma of the Endometrium: A Multi-Institutional Cohort Study.
Front .
Oncol.
12:800957.
doi: 10.
3389/fonc.
2022.
800957.
Front .
Oncol.
12:800957.
doi: 10.
3389/fonc.
2022.
800957.
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