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Front Oncol: Risk factors for locally recurring breast cancer patients and the effect of surgical treatment

 Last Update: 2021-10-20
 Source: Internet
 Author: User

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Breast cancer is the most common cancer worldwide and the main cause of death from cancer in women
.

With a better understanding of the biological behavior of tumor, screening of innovative technologies and integrated multidisciplinary treatment strategy development, more breast cancer at an early stage diagnosis out

Breast cancer is the most common cancer worldwide and the main cause of death from cancer in women

The study retrospectively analyzed early breast cancer patients who underwent surgery in Ruijin Hospital affiliated to Shanghai Jiaotong University from January 2009 to March 2018
.

LRR is defined as recurrence in the ipsilateral breast (IBTR), chest wall, or regional lymph nodes without complicated distant metastasis (DM)

The study retrospectively analyzed early breast cancer patients who underwent surgery in Ruijin Hospital affiliated to Shanghai Jiaotong University from January 2009 to March 2018

A total of 5202 patients were included in the study

After a median follow-up of 47.

Multivariate analysis showed tumor size (p<0.

Multivariate analysis of recurrence related factors

Forty (46.
0%) of 87 LRR patients underwent further salvage surgery
.

Multivariate analysis showed that the size of the primary tumor (p = 0.

Forty (46.

The 5-year OS rates of LRR patients, DM patients, and patients without recurrence were 80.

Comparison of prognosis

The median follow-up time after recurrence was 21.
3 months (range: 1.
0-77.
5), with 30 deaths
.

The PR-OS of patients with LRR as the first event was significantly better than that of DM patients (3-year PR-OS 75.

The median follow-up time after recurrence was 21.

Comparison of prognosis after recurrence

Multivariate analysis showed that ER positive (HR = 0.
33, 95% CI 0.
12 0.
91, p = 0.
033) and LRR salvage surgery (HR = 0.
11, 95% CI 0.
02 0.
93, p = 0.
043) were independent of the improvement of PR-OS in LRR patients Related
.

In summary, studies have shown that in modern breast cancer treatments, the LRR rate is relatively low
.
Tumor size and lymph node status are related to the risk of LRR, and salvage surgery for selected LRR patients has achieved good results
.
Studies have shown that in modern breast cancer treatments, the LRR rate is relatively low
.
Tumor size and lymph node status are related to the risk of LRR, and salvage surgery for selected LRR patients has achieved good results
.
Studies have shown that in modern breast cancer treatments, the LRR rate is relatively low
.
Tumor size and lymph node status are related to the risk of LRR, and salvage surgery for selected LRR patients has achieved good results
.

Original source:

Huang J, Tong Y, Chen X and Shen K (2021) Prognostic Factors and Surgery for Breast Cancer Patients With Locoregional Recurrence: An Analysis of 5,202 Consecutive Patients.
Front.
Oncol.
11:763119.
doi: 10.
3389/fonc.
2021.
763119

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