 Home > Active Ingredient News > Antitumor Therapy > Front Oncol: High serum OPG level is a poor prognostic factor for patients with hepatocellular carcinoma (HCC)

Front Oncol: High serum OPG level is a poor prognostic factor for patients with hepatocellular carcinoma (HCC)

 Last Update: 2021-10-10
 Source: Internet
 Author: User

Tags

surgical 10 blade

level pcb

Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

A number of studies have reported that tissue or serum osteoprotegerin (OPG) levels are prognostic factors for cancer patients
.

However, the role of serum OPG in hepatocellular carcinoma (HCC) remains unclear

A number of studies have reported that tissue or serum osteoprotegerin (OPG) levels are prognostic factors for cancer patients

From 2010 to 2018, 386 eligible HCC patients underwent radical hepatectomy from Shanghai Ninth People's Hospital and Zhongshan Hospital were included
.

Kaplan-Meier curve, Cox regression model and restricted mean survival time (RMST) were used to evaluate the relationship between OPG and survival outcome of HCC patients

From 2010 to 2018, 386 eligible HCC patients underwent radical hepatectomy from Shanghai Ninth People's Hospital and Zhongshan Hospital were included

All patients underwent radical hepatectomy

Before unmatched, patients with high OPG levels had better OS (HR: 1.

OS and DFS before mismatch

After matching, patients with high OPG levels also had OS (HR: 1.
85; 95% CI: 1.
25–2.
74, p=0.
002) and DFS (HR: 1.
71; 95% CI: 1.
20–2.
44, p=0.
003) than patients with low OPG levels.
Worse
.

After matching, patients with high OPG levels also had OS (HR: 1.

OS and DFS after matching

According to the stratified analysis of negative and positive AFP, high OPG levels are also unfavorable factors for OS
.

According to the hierarchical analysis of GGT levels, it is found that high OPG levels are also unfavorable factors for DFS

According to the stratified analysis of negative and positive AFP, high OPG levels are also unfavorable factors for OS

Hierarchical analysis of AFP and GGT

In summary, studies have shown that high serum osteoprotegerin (OPG) levels are a poor prognostic factor for patients with hepatocellular carcinoma (HCC)
.

Studies have shown that high serum osteoprotegerin (OPG) levels are a poor prognostic factor for patients with hepatocellular carcinoma (HCC)

Original source:

Zhang C, Lin J, Ni X, et al (2021)Prognostic Value of Serum Osteoprotegerin Level in Patients With Hepatocellular Carcinoma Following Surgical Resection.

Zhang C, Lin J, Ni X , et al (2021) Prognostic Value of Serum Osteoprotegerin Level in Patients With Hepatocellular Carcinoma Following Surgical Resection Front Oncol 11:.
.
.
731989.
doi: 10.
3389 / fonc.
2021.
731989 in this message

This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.