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Front Oncol: Exploring risk factors and prognosis of gastric adenocarcinoma with bone metastases based on a large population cohort

 Last Update: 2022-04-23
 Source: Internet
 Author: User

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Recently, Frontiers in Oncology published a study from a team from Shanghai Jiaotong University to explore factors associated with gastric adenocarcinoma (GaC) bone metastases, and time-dependent cumulative mortality and prognostic factors in patients with GaC bone metastases.

.

The aim of this study was to explore factors associated with gastric adenocarcinoma (GaC) bone metastases, as well as time-dependent cumulative mortality and prognostic factors in patients with GaC bone metastases

A total of 11,072 eligible metastatic GaC patients were enrolled, including 1511 (14%) patients with bone metastases and 9561 (86%) patients with other metastases
.

The proportion of patients with bone metastases ≤ 50 years was higher (21% vs 15% and 9%), while the proportion of patients ≥ 80 years was lower (8% vs 14% and 22%)

A total of 11,072 eligible metastatic GaC patients were enrolled, including 1511 (14%) patients with bone metastases and 9561 (86%) patients with other metastases

In patients with metastatic GaC, bone metastases diagnoses were more common in 2014 or later (or = 1.
14) and in younger patients (OR <50 years vs 60-69 years = 1.
21, OR ≥ 80 years vs 60-69 years = 0.
56) in SRCs (OR = 1.
33); less common in black patients (OR = 0.
82), in fundus/body cancers (OR = 0.
76) and antral/pyloric cancers (OR = 0.
61), in high It was less common in differentiated (OR = 0.
48) and moderately differentiated/undifferentiated carcinomas (OR = 0.
61)
.

Bone metastases were associated with brain metastases (OR = 2.

In patients with metastatic GaC, bone metastases diagnoses were more common in 2014 or later (or = 1.

No significant differences were found in stratified survival analysis according to factors associated with bone metastases
.

No significant differences were found in stratified survival analysis according to factors associated with bone metastases

Among all patients, 6-month mortality was already as high as 56%; 1-year mortality was 74%, and 2-year (83%) and 3-year (85%) mortality were similar
.

Patients who received chemotherapy had lower mortality rates than those who did not receive chemotherapy or who received chemotherapy unknown within one year (eg, 6 months, 46% vs.

Among all patients, 6-month mortality was already as high as 56%; 1-year mortality was 74%, and 2-year (83%) and 3-year (85%) mortality were similar

Taken together, studies have shown that, in GaC patients, bone metastasis is associated with various clinicopathological factors, including age, ethnicity, tumor location, histology, differentiation, and metastasis at other sites
.

The prognosis of patients with bone metastases is poor and is related to ethnicity, tumor location, lymph node involvement, and treatment

Original source:

Huang L, Zhao Y, Shi Y, Hu W and Zhang J (2022) Bone Metastasis From Gastric Adenocarcinoma—What Are the Risk Factors and Associated Survival? A Large Comprehensive Population-Based Cohort Study.
Front.
Oncol.
12:743873.
doi : 10.
3389/fonc.
2022.
743873

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