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Front Oncol: Efficacy of induction chemotherapy combined with intensity-modulated radiotherapy (IMRT) in the treatment of patients with simultaneous metastatic nasopharyngeal carcinoma

 Last Update: 2021-10-20
 Source: Internet
 Author: User

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Recently, Frontiers in Oncology published the results of a study completed by the Shanghai Fudan University team, mainly to evaluate the efficacy and impact of induction chemotherapy + intensity-modulated radiotherapy (IMRT) in patients with nasopharyngeal carcinoma initially diagnosed with distant metastasis Prognostic factors
.

diagnosis

129 patients were included
.

All patients were histologically confirmed as nasopharyngeal carcinoma (WHO II/III type)

129 patients were included

The median number of cycles of induction chemotherapy is 6 (range 2-12)

Treatment characteristics

Treatment characteristics Treatment feature

Twenty-two patients (17.
0%) who failed first-line treatment received salvage treatment : 16 patients (12.
4%) received TP or GP regimen, and the remaining patients received single-agent chemotherapy ( capecitabine or gemcitabine or tegafur, gemacil) )
.

Twenty-two patients (17.

In this study, no patients died from treatment-related toxicity

Treatment-related toxicity

Treatment-related toxicity of treatment-related toxicity

Univariate analysis showed that the negative prognostic factors of OS include: SLDH (serum lactate dehydrogenase)>180U/L (P=0.
008), multiple bone metastases (P=0.
012), M1 stage subdivision (P<0.
001), radiation Dose <66 Gy (P=0.
017), chemotherapy cycle <4 or >6 (P=0.
017), occurrence of new metastases (P=0.
017)
.

A multivariate analysis of potential adverse prognostic factors showed that the significant adverse prognostic factors were SLDH>180U/L (HR = 1.

Univariate analysis showed that the negative prognostic factors of OS include: SLDH (serum lactate dehydrogenase)>180U/L (P=0.

Multivariate analysis of OS related factors

The 5-year OS rate of patients with multiple bone metastases was 31.
5%, which was significantly lower than that of patients with single bone metastases (58.
9%)
.

The 5-year OS (59.

The 5-year OS rate of patients with multiple bone metastases was 31.

Subgroup analysis prognosis

Different subtypes of M1 stage are significantly related to survival rate
.

The 5-year OS rate was 62.
6% in the M1a group, 40.
4% in the M1b group, and 0% in the M1c group
.
In addition, patients who received 4 to 6 cycles of chemotherapy had a better 5-year OS rate than patients who received 4 cycles of chemotherapy (53.
3% vs.
22.
2%)
.

Different subtypes of M1 stage are significantly related to survival rate
.
The 5-year OS rate was 62.
6% in the M1a group, 40.
4% in the M1b group, and 0% in the M1c group
.
In addition, patients who received 4 to 6 cycles of chemotherapy had a better 5-year OS rate than patients who received 4 cycles of chemotherapy (53.
3% vs.
22.
2%)
.
Different subtypes of M1 stage are significantly related to survival rate
.
The 5-year OS rate was 62.
6% in the M1a group, 40.
4% in the M1b group, and 0% in the M1c group
.
In addition, patients who received 4 to 6 cycles of chemotherapy had a better 5-year OS rate than patients who received 4 cycles of chemotherapy (53.
3% vs.
22.
2%)
.

In summary, studies have shown that platinum-containing induction chemotherapy combined with intensity-modulated radiotherapy can improve the prognosis of some patients with simultaneous metastatic nasopharyngeal carcinoma
.
Related factors predicting OS include SLDH before treatment, the number of chemotherapy cycles, and different stages of M1
.
More randomized controlled studies are needed in the future to confirm this
.
Studies have shown that platinum-containing induction chemotherapy combined with intensity-modulated radiotherapy can improve the prognosis of some patients with simultaneous metastatic nasopharyngeal carcinoma
.
Related factors predicting OS include SLDH before treatment, the number of chemotherapy cycles, and different stages of M1
.
More randomized controlled studies are needed in the future to confirm this
.
Studies have shown that platinum-containing induction chemotherapy combined with intensity-modulated radiotherapy can improve the prognosis of some patients with simultaneous metastatic nasopharyngeal carcinoma
.
Related factors predicting OS include SLDH before treatment, the number of chemotherapy cycles, and different stages of M1
.
More randomized controlled studies are needed in the future to confirm this
.

Original source:

Ni M, Geng L, Kong F, Du C, Zhai R, Lyu Y, Hu C and Ying H (2021) Induction Chemotherapy Combined With Intensity-Modulated Radiotherapy for 129 Nasopharyngeal Carcinoma Patients With Synchronous Metastases: A Retrospective Study.
Front.
Oncol .
11:654871.
doi: 10.
3389/fonc.
2021.
654871

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