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Front Oncol: Differences in clinical characteristics and clinical prognosis of patients with non-metastatic non-clear cell renal cell carcinoma (non-ccRCC)

 Last Update: 2022-01-23
 Source: Internet
 Author: User

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Non-clear cell renal cell carcinoma (non-ccRCC) includes histologically and molecularly distinct subtypes, such as papillary, chromophobe, collecting duct, and sarcomatoid RCC, with an incidence of 20% to 25%

The study used the National Cancer Database to screen patients with non-metastatic RCC (T1-4, N0-1) between 2004 and 2015

Overall, our analysis included 220,170 patients with RCC

The median follow-up time for patients with all histological subtypes was 48.

Differences in prognosis of non-clear cell renal cell carcinoma (non-ccRCC) subtypes

Multivariate analysis included 6723 chromophobe, 188 collecting duct, 19086 papillary, and 1083 sarcomatoid RCC

Well-differentiated (HR = 0.

In terms of surgical treatment, no surgery (HR = 2.

Regional lymph node surgery was associated with worse survival outcomes compared with surgery without regional lymph nodes (HR = 1.

Taken together, our study demonstrated that collecting duct and sarcoid histological subtypes are less common and associated with poorer postoperative survival compared with other RCC subtypes

Original source:

An J, Packiam VT, Chennamadhavuni A, Richards J, Jain J, Mott SL and Garje R (2022) Patient Characteristics and Survival Outcomes of Non-Metastatic, Non-Clear Cell Renal Cell Carcinoma.

An J, Packiam VT, Chennamadhavuni A, Richards J, Jain J, Mott SL and Garje R (2022) Patient Characteristics and Survival Outcomes of Non-Metastatic, Non-Clear Cell Renal Cell Carcinoma.
Front.
Oncol.
11:786307.
doi : 10.
3389/fonc.
2021.
786307

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