Front Oncol: Combined radiotherapy on the basis of chemotherapy can improve the prognosis of patients with locally advanced or metastatic esophageal squamous cell carcinoma

Recently, Frontiers in Oncology published a study from the Radiotherapy Department of Guangxi Medical University Affiliated Cancer Hospital, mainly to evaluate the combination of chemotherapy and radiotherapy (CRT) versus chemotherapy alone in patients with locally advanced or metastatic esophageal squamous cell carcinoma.

We retrospectively evaluated 194 newly diagnosed patients with advanced esophageal squamous cell carcinoma who received CRT or CT, including 97 patients with locally advanced disease and 97 patients with distant metastases

Of the 194 patients, 101 (52.

Before matching, median OS at 6, 12, 24 and 60 months was better in the CRT group than in the CT group (12.

There were also significant differences in PFS and OS between the CRT and CT groups after adjusting for all baseline factors

Among patients with metastatic ESCC, the median OS, 6, 12, 24, and 60-month OS rates were better in the CRT group than in the CT group (12.

In multivariate analysis of the pre-matching cohort, the addition of radiotherapy, albumin levels, absolute neutrophil counts, and number of chemotherapy cycles were OS (p = 0.

In conclusion, studies have shown that chemotherapy combined with radiotherapy can improve the prognosis of patients with locally advanced or metastatic esophageal squamous cell carcinoma

Original source:

Li LQ, Fu QG, Zhao WD, Wang YD, Meng WW and Su TS (2022) Chemoradiotherapy Versus Chemotherapy Alone for Advanced Esophageal Squamous Cell Carcinoma: The Role of Definitive Radiotherapy for Primary Tumor in the Metastatic Setting.