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    Home > Active Ingredient News > Antitumor Therapy > Front Oncol: A retrospective study comparing nab-paclitaxel and docetaxel as neoadjuvant therapy in patients with HER2- breast cancer

    Front Oncol: A retrospective study comparing nab-paclitaxel and docetaxel as neoadjuvant therapy in patients with HER2- breast cancer

    • Last Update: 2022-01-23
    • Source: Internet
    • Author: User
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    The efficacy of nab-paclitaxel as neoadjuvant chemotherapy in patients with HER2- breast cancer is unclear


    breast cancer

    This study retrospectively analyzed patients with HER2-negative breast cancer who underwent neoadjuvant therapy and surgery from May 2016 to April 2018


    The study included 159 patients, including 79 in the nab-paclitaxel group and 80 in the docetaxel group


    The ORRs of the albumin-paclitaxel group and the docetaxel group were 89.


    Albumin - paclitaxel and docetaxel ORR group was 89.



    Efficacy assessment

    After subgroup analysis, triple-negative breast cancer (TNBC) patients had a higher pCR rate in the nab-paclitaxel group than in the docetaxel group (62.


    After subgroup analysis, triple-negative breast cancer (TNBC) patients had a higher pCR rate in the nab-paclitaxel group than in the docetaxel group (62.



     Efficacy assessment subgroup analysis

    After a median follow-up of 47 months, 33 of 159 patients (20.




    Taken together, the study demonstrated a higher pCR rate with nab-paclitaxel compared with docetaxel, especially in patients with triple-negative or node-negative breast cancer


    Studies have shown a higher pCR rate with nab-paclitaxel compared with docetaxel, especially in patients with triple-negative or node-negative breast cancer


    Lv ZD, Song HM, Niu ZH, Nie G, Zheng S, Xu YY, Gong W and Wang HB (2022) Efficacy and Safety of Albumin-Bound Paclitaxel Compared to Docetaxel as Neoadjuvant Chemotherapy for HER2-Negative Breast Cancer.


    Lv ZD, Song HM, Niu ZH, Nie G, Zheng S, Xu YY, Gong W and Wang HB (2022) Efficacy and Safety of Albumin-Bound Paclitaxel Compared to Docetaxel as Neoadjuvant Chemotherapy for HER2-Negative Breast Cancer.
    Front.
    Oncol .
    11:760655.
    doi: 10.
    3389/fonc.
    2021.
    760655 Comment

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