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Psoriasis is an immune -mediated skin disease with autoimmune features
.
Obesity, diabetes and mental stress are thought to be risk factors for exacerbating psoriasis
immune diabetes
Nonalcoholic fatty liver disease (NAFLD) includes nonalcoholic fatty liver disease and nonalcoholic steatohepatitis, and is defined as >5% of hepatocellular steatosis in patients with light or no alcohol consumption
.
The prevalence of NAFLD has increased significantly in recent years, with a recent meta-analysis reporting a prevalence of 33.
nonalcoholic fatty liver
Existing observational studies discussing the psoriasis-NAFLD association are mostly limited to small sample sizes and cross-sectional study designs
.
Furthermore, with regard to the inverse relationship, although a possible association has been hypothesized, there is a lack of real evidence on the risk of psoriasis in patients with NAFLD
Research design
Data were retrieved from the Taiwan Health Insurance Research Database
.
New-onset NAFLD patients and psoriasis patients were included in two cohorts
The risk of psoriasis in patients with new-onset NAFLD was statistically significant, with a HR of 1.
07 (95% CI, 1.
01-1.
14)
.
For younger patients with NAFLD, the risk of developing psoriasis was 1.
statistics
Evidence supports a bidirectional association between NAFLD and psoriasis, especially in patients under the age of 40
.
In clinical treatment, the association between these two diseases and the risk of subsequent disease should be considered
Source: Gau SY, Huang KH, Lee CH, Bidirectional Association Between Psoriasis and Nonalcoholic Fatty Liver Disease: Real-World Evidence From Two Longitudinal Cohort Studies.
Gau SY, Huang KH, Lee CH, Bidirectional Association Between Psoriasis and Nonalcoholic Fatty Liver Disease: Real-World Evidence From Two Longitudinal Cohort Studies.
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