Front cellular Neurosci: in-depth analysis of α - synuclein properties is expected to help develop new Parkinson's disease therapies

February 7, 2020 / BIOON / -- recently, an international magazine published in frontier in cellular neuroscience In the previous research report, scientists from the University of buffalo analyzed the α - synuclein through research, which is directly related to the pathogenesis of Parkinson's disease; it will form abnormal clumps in the brain of patients, but now scientists do not know the molecular mechanism and reason behind it Photo source: pl.wikipedia.org in this study, the researchers revealed the basic characteristics of α - synuclein, and focused on the part of the protein called non amyloid component They genetically modified the Drosophila larvae to produce normal and mutated human α - synuclein The researchers say the NAC region appears to help alpha synuclein pass through a channel called axon, which does not move in axons when the NAC region is missing In addition, the researchers also found that the absence of α - synuclein in the NAC region may help to effectively inhibit the unnecessary aggregation of proteins After the study of Drosophila, the researchers pointed out that they may be able to inhibit the key problem of excessive α - synuclein production (protein aggregation); when genetic When the engineered fly larva produces excessive α - synuclein and α - synuclein form without NAC region, the fly larva can crawl normally, the protein will not gather, and the synapse will behave normally According to researcher Gunawardena, in Drosophila larva, we can inhibit some similar symptoms simulating Parkinson's disease, such as the accumulation of α - synuclein in neurons, and the relevant research results are expected to help researchers develop new Parkinson's disease therapy by eliminating the NAC region One of the important reasons for the research results in this paper is that it shows that The pathological manifestations of Parkinson's disease, such as α - synuclein aggregation, synaptic morphological defects and motor defects, were effectively dealt with in the object environment (bio Com) original source: Eric n Anderson, delnessaw hirpa, Kan Hong Zheng, et al The non-metallic component region of α - synuclein is important for α - synuclein transport with axes Frontiers in cellular neuroscience, 2020; 13 doi: 10.3389/fncel.2019.00540