Front Cell Dev Biol: A mother's diet rich in Omega-3 fatty acids can protect offspring from breast cancer

Alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are three important omega-3 (ω-3) fatty acids (FA)
.

ALA is an essential fatty acid, mainly found in vegetable oils, such as rapeseed oil, flaxseed and soybeans

Alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are three important omega-3 (ω-3) fatty acids (FA)

Both ω-3 and ω-6 FA are important structural components of cell membranes and are precursors of various important biochemical transformations
.

Considering the benefits and adverse effects of ω-6 FA, the balance between ω-6 and ω-3 FA (the best ω-6/ω-3 ratio is between 1:1 and 1:3) is essential for a healthy life The way is crucial

Both ω-3 and ω-6 FA are important structural components of cell membranes and are precursors of various important biochemical transformations

A diet rich in omega-3 fatty acids (FA) has been linked to reduce the risk of certain types of cancer

Recently , a study published in the Front Cell Dev Biol research on the show , rich in Omega-3 fatty acids in maternal diet can prevent future generations suffering from breast cancer

To test for protective effect (rapeseed and corn oil enriched diet) on DMBA-induced carcinogenesis maternal diet, to F1 mice injected DMBA (weekly dose of 1 mg, 6 weeks)
.

To test for protective effect (rapeseed and corn oil enriched diet) on DMBA-induced carcinogenesis maternal diet, to F1 mice injected DMBA (weekly dose of 1 mg, 6 weeks)
.

Surprisingly, the researchers observed that compared with F1 generation mice on a corn (Co/Co) oil-rich diet, DMBA-induced mortality was delayed by 3 weeks ( Figure 4A )
.

This early delay in mortality in the canola oil-rich diet ( Ca/Co ) group was statistically significant ( P value <0.

Surprisingly, the researchers observed that compared with F1 generation mice on a corn (Co/Co) oil-rich diet, DMBA-induced mortality was delayed by 3 weeks ( Figure 4A )

Despite this , the tumor development of Co/Co mice is faster than that of Ca/Co mice , and the lateral growth rate of breast tumors is slower.

 Maternal diet can regulate the effect of DMBA on breast tissue of offspring

 Maternal diet can regulate the effect of DMBA on breast tissue of offspring

Since the maternal diet epigenetically regulates various gene promoters, the researchers used Western blotting to perform protein expression analysis to determine whether the expression of proteins responsible for DNA damage repair and epigenetic remodeling after exposure to carcinogens has changed
.

Since the maternal diet epigenetically regulates various gene promoters, the researchers used Western blotting to perform protein expression analysis to determine whether the expression of proteins responsible for DNA damage repair and epigenetic remodeling after exposure to carcinogens has changed
.

It was found that the increase in H3K18ac levels around TSS was associated with a slight increase in the levels of BRCA1, BRCA2, RAD51, and FAN1 proteins in Ca/Co mice compared with Co/Co mice that responded to DMBA
.

It was found that the increase in H3K18ac levels around TSS was associated with a slight increase in the levels of BRCA1, BRCA2, RAD51, and FAN1 proteins in Ca/Co mice compared with Co/Co mice that responded to DMBA
.

It is worth noting that, compared with the Co/Co mice before DMBA treatment, the transcriptional expression of Brca1 was reduced ( P value <0.
01), and there was no change in Fan1 in Ca/Co mice .
In addition, compared with Co/Co mice, PRMT2 protein expression was relatively increased ( P value, ns), but the CHD1 and SMARCA5 in Ca/Co did not change; however, before DMBA treatment, Prmt2 in Ca/Co mice The transcription level of Chd1 and Chd1 genes did not change, while Smarca5 increased significantly ( P value <0.
01) .

It is worth noting that, compared with the Co/Co mice before DMBA treatment, the transcriptional expression of Brca1 Brca1 was reduced ( P P value <0.

01), and there was no change in Fan1 Fan1 in Ca/Co mice .
Further, as compared with Co / Co mice, PRMT2 relative increase in protein expression ( P P value, NS), but the Ca / Co and the CHD1 SMARCA5 no change; however, prior to DMBA treatment, mice Ca / Co Prmt2 Prmt2 and Chd1 Chd1 gene transcription levels did not change, but Smarca5 Smarca5 significantly increased ( P P value <0.
01) .

Taken together, these findings suggest that maternal diet rich in rapeseed oil epigenetically regulates transcriptional expression and epigenetically enhances various genes, possibly for rapid activation in the event of carcinogenic damage to prevent the development of breast tumors
.

Taken together, these findings suggest that maternal diet rich in rapeseed oil epigenetically regulates transcriptional expression and epigenetically enhances various genes, possibly for rapid activation in the event of carcinogenic damage to prevent the development of breast tumors
.

Georgell, a professor in the Department of Biological Sciences at Marshall University, said: "Parents' diet and intergenerational transmission have become an important research area; however, the mode of action is often still partially elusive
.
" "The MU research team focuses on the'appearance of intergenerational transmission .
" Genetics' aspect to explain the reported role of Omega-3 fatty acids
.
Epigenetics involves changes in gene expression that are not related to changes in gene sequence
.
These results may promote simple dietary changes designed to reduce the occurrence of various types of cancer , Not just for individuals who use the dietbut also for their offspring .
"

Georgell, a professor in the Department of Biological Sciences at Marshall University, said: "Parents' diet and intergenerational transmission have become an important research area; however, the mode of action is often still partially elusive
.
" "The MU research team focuses on the'appearance of intergenerational transmission .
" Genetics' aspect to explain the reported role of Omega-3 fatty acids
.
Epigenetics involves changes in gene expression that are not related to changes in gene sequence
.
These results may promote simple dietary changes designed to reduce the occurrence of various types of cancer and not just for the use of the diet diet of individuals  but also to their offspring
.
"

References : Epigenetic Reprogramming Mediated by Maternal Diet Rich in Omega-3 Fatty Acids Protects From Breast Cancer Development in F1 Offspring Front.
Cell Dev.
Biol.
, 10 June 2021 |  https://doi.
org/10.
3389/fcell.
2021.
682593 

References : Epigenetic Reprogramming Mediated by Maternal Diet in the Rich-Omega.
3 Protects the From Fatty Acids in Breast Cancer Development Fl Offspring Front the Cell Dev Biol, 10 June 2021 |.
.
.
  Https://doi.
org/10.
3389/fcell.
2021.
682593  reference Literature : Epigenetic Reprogramming Mediated by Maternal Diet Rich in Omega-3 Fatty Acids Protects From Breast Cancer Development in F1 Offspring Epigenetic Reprogramming Mediated by Maternal Diet Rich in Omega-3 Fatty Acids Protects From Breast Cancer Development in F1 Offspring Front.
Cell Dev.
Biol .
, 10 June 2021 |  https://doi.
org/10.
3389/fcell.
2021.
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