Four-ring lyophilization experimental lyophilizer should pay attention to some matters during use

Four-ring lyophilization experimental lyophilizer is a kind of drying equipment, which is composed
of refrigeration system, vacuum system, heating system, electrical instrument control system.

What are the benefits of using a lyophilizer? 1.
By drying at low temperatures, many heat-sensitive substances, such as proteins, microorganisms, etc.
, will not denature or lose biological vitality
.

2.
Because it is dried in a frozen state, it can protect the volume of the product from not changing much, and keep the original structure from concentrating
.

3.
Usually the material after the lyophilizer is dried loose and porous as a sponge, which dissolves quickly after adding water and can restore the original properties
.

4.
Since less oxygen is required for conducting under vacuum, it is suitable for the drying of substances that are easy to oxidize
.

5.
In the freeze-drying process, the growth of microorganisms and the action of enzymes cannot be carried out, so the original traits can be maintained
.

6.
Lyophilizer drying can eliminate more than 95-99% of the water, so that the product is not easy to deteriorate
for long-term storage.

In order to use the rate of the four-ring lyophilization experimental lyophilizer or the safety of use, we all need to pay attention to some matters during use: 1, the preparation of the sample should be as large as possible to expand its surface area, which must not contain acids and alkalis and volatile organic solvents; 2.
The sample must be completely frozen into ice, and if there is residual liquid, it will cause gasification and injection; 3.
Note that the cold trap is about minus 65 degrees, which can be used as a low-temperature refrigerator, but it must be operated with thermal insulation gloves to prevent frostbite; 4.
Before starting the four-ring pump, check whether the outlet valve is tightened, whether the inflatable valve is closed, and whether the contact surface between the plexiglass cover and the rubber ring is clean and free of dirt and well sealed; 5.
Under normal circumstances, the machine shall not be used continuously for more than 48 hours; 6.
During the freezing process, the temperature of the sample is gradually reduced, and the sample can be taken out to warm up for a period of time (still in the frozen state), and continue to dry to shorten the drying time
.