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For the treatment of chronic lymphocytic leukemia, the bispecific γδ T cell binding antibody LAVA-051 obtained FDA orphan drug certification

 Last Update: 2021-10-20
 Source: Internet
 Author: User

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Clinical-stage biotechnology company LAVA Therapeutics NV today announced that the US Food and Drug Administration Administration ( the FDA ) has granted orphan drug certification (ODD) the company's targeted CD1d LAVA-05 for the treatment of chronic lymphocytic leukemia (CLL)
.

Manage FDA

CLL is an indolent lymphoproliferative disease characterized by the progressive accumulation of abnormal lymphocytes in peripheral blood, bone marrow, and lymphoid tissues, among which monoclonal B lymphocytes (＞5 x 10⁹/L [＞5 x 10³/μL) ]) Mainly found in peripheral blood (Figure 1)
.

If these cancer cells are mainly found in the lymph nodes, the disease is called small lymphocytic lymphoma

Lymphoma

Figure 1.
Monoclonal B lymphocytes in peripheral blood

LAVA-051 is a bispecific antibody that preferentially activates Gamma Delta T cells and type 1 natural killer T (NKT) cells to recruit the immune system to attack CD1d-expressing cancer cells
.

LAVA-051 is composed of two single domain antibodies connected by a short five amino acid glycine-serine linker

LAVA-051 is a bispecific antibody that preferentially activates Gamma Delta T cells and type 1 natural killer T (NKT) cells to recruit the immune system to attack CD1d-expressing cancer cells

LAVA Therapeutics President and CEO Stephen Hurly said: "We are very pleased to receive FDA orphan drug for the first certification LAVA-051, and this will help to strengthen our designated with the FDA on the development of LAVA-051 communication"

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