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Image: Schematic summary of new hippocampal circuit connections revealed in the latest PLOS Biology study
Source: UCI School of Medicine
A team of researchers led by the University of California, Irvine has discovered new neural circuits that regulate spatial learning and memory in the formation of the brain's hippocampus
The study, "Atypical projections of hippocampal CA3 regulate spatial learning and memory by modulating feedforward hippocampal trisynaptic pathways," is published today in the journal PLOS Biology
The hippocampus is not a single brain region
"Our findings extend knowledge about hippocampal connectivity and its relationship to learning and memory processes, and provide a circuit basis for exploring these new functional roles
Building on their earlier work, Xu and his team used a variety of viral tracers, including monosynaptic rabies retrograde tracing and herpes (H129)-based anterograde tracing to establish new hippocampal CA1 to CA3 projections
"The advent of viral gene mapping technology has enhanced our ability to determine the complexity of the details of brain circuits," Xu said
article title
Non-canonical projections to the hippocampal CA3 regulate spatial learning and memory by modulating the feedforward hippocampal trisynaptic pathway
