For the first time, changes in the brain's life were observed at synaptic levels.

Recently, a paper entitled "A brain-wide of synapses and the mouse" was published in the journal Science, a leading international journal.
researchers at the University of Edinburgh in the UK used a panoramic view of the single synaptic plane in genetically modified mice through tissue-slicing fluorescence imaging and gene sequencing techniques to show changes in the structure and function of the entire brain in the mouse's lifetime.
synapses are the basic unit that make up the neural loop activity and are the key parts of functional connections between neurons.
synapses directly affect the brain's cognition and behavior.
are closely related to a variety of brain diseases, such as abnormal behavioral development, adult mental disorders, neurodegenerative lesions, etc.
the researchers first constructed genetically modified mice that could simultaneously express fusion fluorescent-labeled synaptic proteins PSD95 and SAP102, used turntable confocal microscopes to observe PSD95 and SAP102 expression at single synaptic resolution, and divided synapses into 3 categories and 37 subtypes using machine learning. secondly,
, by dynamically tracking the number and type changes in the 12 brain regions of the brain from birth to adulthood, it was found that synapses increased with age and showed significant diversity, especially in the cerebral cortex, subcortex and hippocampus region, and there were significant differences in synaptic types between brain regions.
finally, the researchers focused on the sea immediately, which is closely related to cognitive, memory, and spatial perception, and found that the expression of PSD95 and SAP102 had significant differences in space-time distribution in CA1 cone neurons, and that there were dynamic changes between different regions of the hippocampus, which they believed were closely related to changes in learning and memory.
the authors of the paper say the findings will help us understand how the brain changes in cognitive, memory, and behavioral abnormalities, providing new tools for revealing brain development, aging, and disease.
()