Focus on brain health! These research results are worth reading!

!-- webeditor:page title" -- In this article, we have compiled several important research results to focus on brain health-related research and share them with you! Photo Credit: Pixabay/CC0 Public Domain1 J Neurosci: Key proteins regulate brain development doi:10.1111/jnc.15149 Normal brain development requires precise interaction between neurons and non-neuron (also known as glial) cells.
a new study by researchers at Tsukiji University in Tsukiji, California, sheds light on how the loss of the protein arginine methyl transferase (PRMT)1 causes glial cells to rupture and affect normal brain development.
prMT modifies specific amino acids from other proteins to regulate key functions of cells, such as survival, proliferation and development.
of the many members of the PRMT family identified to date, PRMT1 is one of the most common members, controlling tissue development and longevity, as well as stress response.
Because the complete knockout of PRMT1 (i.e., the loss of proteins in all tissues during development) leads to embryonic development failure, more rigorous research has recently been conducted on tissue specific knockout of PRMT1 to understand how PRMT1 promotes tissue development.
new discovery! Reproductive cells may like to "eat sweets" and pass this trait on to the body's brain! Doi:10.1038/s42255-020-0266-x Our work seems to be easy compared to cells, and when cells work hard to break down some molecules and build others, all we do is feed them, but what exactly should we feed them? Given the ongoing competition within, this may not be an easy question to solve: cell types such as fat cells crave lipids, while other types of cells prefer proteins or sugars, and how do we consider and make decisions about all competitive needs when our brains are faced with difficult choices such as steak or ice cream? In a recent study published in the international journal Nature Metabolism entitled "Cellular metabolic reprogramming controls sugar appetite in Drosophila", scientists from institutions such as the Champaleimaud Research Centre in Portugal found that changes in the nutritional needs of sexual cells or It makes female fruit flies more sugar-hungry, a phenomenon described so far mainly in pathological conditions, namely cancer, which researchers discovered during the normal physiological process of egg formation, or provides a basis for later clarification of the relationship between fertility and nutrition in the body.
small group of cells affect the behavior of the entire organism? The answer may come from oncology research, where when a cell becomes cancerous, the gas turns on the sugar-consuming cell and its components and transforms it into the basic building block needed for cell reproduction, in which the cell changes its dietary preferences and function, known as metabolic reproduction, which is key to tumor growth.
this phenomenon also appears to have been documented in irrational processes, but researchers don't know whether the metabolic transformation of cells hijacks an organism's feeding decisions, which may be a question that researchers need to delve into later.
scientists hope to unlock the mysteries of the brain! Doi:10.1038/s41467-020-17861-7 In a recent study published in the international journal Nature Communications entitled "A spike-timing-dependent plasticity rule for dendritic spines", scientists from institutions such as the University of Montreal have uncovered the molecular mechanisms behind the body's memory and learning abilities, in particular how the brain handles, stores and integrates information.
paper, the researchers analyzed the function and morphological transformation of synapses, tiny protrusions located on neuron branches that are thought to be the underlying mechanisms behind brain learning and memory. 'We're very excited because this is the first time we've found the rules of synaptic plasticity, a process directly related to brain memory formation, which allows researchers to understand plasticity and how memory is formed when neurons in the cerebral cortical layer receive a single or multiple stream of sensory information,' said Araya, a researcher at
.
The brain is made up of billions of excited neuron cells that are responsible for communication and information processing; Represented by synapses, the leaves are represented by a tyrule, and these thousands of small leaves act as a channel for receiving excitable information from other cells, which determines whether the information is important enough to be amplified and transmitted to other neuron cells.
: Reprogramming brain cells may help the body make more flexible decisions doi:10.1038/s41586-020-2704-z Avoid shaking hands when greeting, wearing a mask on a train, sneezing at the elbow, etc. The prevalence of the COVID-19 outbreak dramatically shows how important it is for humans to get rid of their habits and learn new ones, and that animals must be able to adapt quickly to changes in environmental conditions; in a recent study published in the international journal Nature, scientists from institutions such as the University of Zurich in Switzerland found that reprogramming brain cells may help the body make more flexible decisions.
researcher Professor Fritjof Helmchen says the brain's plasticity forms the basis for its ability, but scientists may not yet know the biological mechanism behind it, and in this study we found that the prefrontal cortex of the brain, located behind the eye, may be able to reprogram neuron cells located in the sensory region of the body.
!--/ewebeditor:page--!--ewebeditor:page title"--By studying mice, the researchers simulated their re-learning process under controlled conditions and studied changes that occurred at a single neuron level during the learning process, first training mice to lick each time they came into contact with coarse sandpaper with their beards, while rewarding them with a glass of sugar water. However, when mice rub their beards with fine sandpaper, they are not allowed to lick them, and if they do, they are punished and make a slight annoying sound, which changes once the mice understand how to accomplish their tasks, and now, when the mice are studied with fine sandpaper instead of coarse sandpaper, the rewards are sent to the mice, who, after a little practice, quickly learn the opposite pattern.
5 ( 5) Too much or too little sleep is bad for the brain Reading News Read: Too much or too little sleep bad your for brain A new study shows that everyone needs sleep, but too little or too much sleep can lead to a decline in thinking.
sleep deprivation is defined as four hours or less a night, while excessive sleep is considered 10 or more a night.
ideal sleep time is seven hours.
according to the National Sleep Foundation, sleep is essential because it can re-reseed your body and mind.
amount of sleep can also help you stay healthy and prevent disease.
enough sleep, the brain will not function properly, impairing attention, thinking and memory processing.
, the underlying mechanisms of these associations remain unclear.
recent studies, too much sleep may be associated with an increased response to inflammation in the brain.
, lack of sleep may increase levels of amyloid plaques and tau proteins in the cerebrospinal fluid, a hallmark of Alzheimer's disease.
photo source: Zita Santos and Carlos Ribeiro (6) Brain Interpretation: Scientists may be promising to use new gene therapies to treat multiple human brain diseases doi:10.1093/brain/awaa161 A single gene mutation can trigger a life-changing disease and affect multiple systems in the body. For example, dozens of lysosome storage diseases, caused by a single gene mutation that affects the production of key enzymes that metabolize large molecules in cells, affect the function of multiple organs of the body, especially the brain, which can cause varying degrees of intellectual disability, and gene therapy may be expected to treat these diseases, but the brain's own protective mechanism, the blood-brain barrier, has been a technical barrier for researchers.
recently, scientists from the University of Pennsylvania and others successfully applied gene therapy platforms to correct brain defects in large animal models of human genetic diseases in a study published in the international journal Brain entitled "Global CNS correction in a large brain model of human alpha-mannosidos by intravascular gene therapy".
researcher John H. Wolfe says it's the first animal model to have a human genetic disorder that exhibits intellectual disabilities (part of human syndrome) and can now correct bio-chemical and pathological damage throughout the brain; With the help of gene therapy, a viral transport vector could provide a normal version of the mutant gene to correct the disease, and now researchers have made some progress, or are expected to treat neurodegenerative diseases in rodents, but applying the same treatment to the larger brains of higher animals may only have a partial effect on disease correction.
7 (Xinhua) -- Mitochondrials may promote the transformation of neural stem cells to neuron cells during brain development Doi:10.1126/science.aba9760 Mitochondrials are small organs that are important for providing energy to every cell in the body, especially for brains that need energy to maintain normal function, according to a study published in the international journal Science, among others. Scientists have found that mitochondrials may be able to regulate key events during brain development, namely how to regulate the transformation of neural stem cells into nerve cells; mitochondrials experience the switch that affects the fate of cells at this precise time, twice the length of a mouse; and the findings highlight the important function of mitochondrials, which may help researchers explain why humans develop larger brains during evolution, and how mitochondrial defects can induce neurodevelopmental diseases.
The brain is made up of billions of different neurons, and when stem cells stop self-renewal and differentiate into special types of neurons, they first appear in the developing brain, a process known as neurogenesis, which is precisely regulated to produce complex structures in the brain, and researchers believe that small differences in the way neural stem cells produce neurons may be the source of the increased size and complexity of the brain.
in-depth analysis of the process, the researchers conducted an in-depth study of mitochondrials in cells.
: Long-term high blood pressure may damage the brain's vascular health doi:10.1161/HYPERTENSIONAHA.120.15073 In a recent study published in the international journal Hypertension, scientists from the University of Michigan School of Medicine and others found that long-term High blood pressure may increase the risk of small blood vessel damage in the brain, which is often directly related to dementia and stroke risk; it has long been known that high blood pressure leads to stroke, but past studies have only linked high blood pressure to alzheimer's disease risk, and in this new study, researchers focused on how high blood pressure affects the brain's small vascular lesions, the most frequent cerebrovascular disease in stroke and dementia.
!--/ewebeditor:page--!--ewebeditor:page-title--" -- the researchers studied 1,686 adults who did not have a stroke or dementia at the start of the study and analyzed participants The researchers measured blood pressure in middle age and performed MRIs scans of different parts of the brain to check for micro-bleeding in the brain, accumulation of small-scale blood products in brain tissue, and brain tissue death, all of which are signs of small vascular lesions in the brain.
: Can eating more fish really protect the brain from air pollution? doi:10.1212/WNL.0000000000010074, published in the international magazine Neurology entitled "Erythrocyte omega-3 index, In their study, scientists from Columbia University and others found that older women may get enough omega-3 fatty acids to offset the adverse effects of air pollution on the brain if they eat more than 1-2 servings of grilled fish or shellfish a week.
study, researchers studied older women without dementia and analyzed whether LCn3PUFA, an omega-3 fatty acid, modifies the nerves of PM2.5 to the brain's normal brain volume.