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Flt3 inhibitor AML produces CR: talk about off-target...

 Last Update: 2021-03-29
 Source: Internet
 Author: User

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Today Aptose Bioscience announced that its multi-kinase inhibitor Luxeptinib (formerly known as CG-806) produced a complete response in the early clinical stage of an acute myeloid leukemia (AML).

Drug source analysis

Luxe was originally developed as a reversible BTK inhibitor and its main use is chronic leukemia, but so far it is still a substitute goalkeeper in this arena.

One potential problem with covalent compounds is the so-called off-target side effects.

But even patients with off-target side effects of serious diseases such as tumors sometimes can't bear it, and Luxe came into being.

Off-target activity is one of the main differences between small molecule drugs and biological drugs.

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Flt3 inhibitor AML produces CR: talk about off-target activity

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Flt3 inhibitor AML produces CR: talk about off-target...

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Flt3 inhibitor AML produces CR: talk about off-target activity