First acquaintance with thalassemia

What is thalassemia? Thalassemia is an autosomal recessive disease that was called "thalassemia" at the time because it was first detected in the Mediterranean region

Case passed

2022.

Figure 1

Peripheral blood smear microscopy is shown in Figure 2

Figure 2 (Regis staining X1000)

According to the results of routine blood and peripheral blood smear examination, it is recommended to prescribe relevant tests such as iron metabolism, hemoglobin electrophoresis, erythrocyte osmotic fragility experiment and geopoor genetic detection

Other laboratory-related tests are shown in Figures 3 and 4

Figure 3

Figure 4

Case

analyse

How to give initial clinical advice only through blood routine testing? Thalassemia patients with peripheral blood smear Regis staining microscopic examination can show uneven red blood cell size and abnormal erythrocyte hyperplasia, including spherocytes, basophilic dotted red blood cells, target red blood cells, teardrop red blood cells and other special-shaped red blood cells, with the aggravation of anemia symptoms, the more obvious the abnormality, the peripheral blood smear of this patient can see red blood cells showing small cell hypochromic anemia, target red blood cells are rare

Case summary

Thalassemia is an anemia or pathological state

Case experience

Blood routine is a reflection of the number, form, proportion of various blood cells in the blood whether the examination report is normal, grass-roots hospitals can also be carried out, the significance of which is to be able to quickly screen for certain diseases, diagnose whether infection, anemia, bleeding, whether there are blood system diseases, bone marrow hematopoietic dysfunction and other diseases

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