Find the key protein to control breast cancer metastasis!

A study led by Roger Gomis, a scientist at the icrea Institute of biomedical research (IRB), found genes related to the asymptomatic latency of breast cancer metastases This work has brought light to reveal the molecular mechanism of gene expression promoting cancer metastasis Different breast cancer patients have different time of metastasis, but scientists don't know much about the mechanism of controlling the incubation period The team studied estrogen positive (ER -) breast cancer, the most common breast cancer, accounting for 80% of breast cancer cases The research team is interested in long-term latent breast cancer The research results are published in nature cell biology The team found that protein kinase MSK1 is a key regulator of latent metastasis Using tissue samples from clinical patients, scientists found that ER + patients who did not express MSK1 had earlier metastasis, while those who expressed the protein had later metastasis "We would like to know the mechanism behind the timing of the transfer So far, we know very little about the mechanism of keeping breast cancer cells in incubation period in preclinical model, let alone patients " Roger Gomis said he is the head of the growth control and cancer metastasis laboratory The researchers believe that the research will benefit patients in the future by two ways: one is to help identify patients who will soon have metastasis to adjust the treatment plan to prevent metastasis; the other is to help design drugs that simulate the function of MSK1, so that the metastasis can be in the incubation period as long as possible.