Find immune cells for tumors in 1 day! Wu Peng's team brings new tools for immunotherapy.

Using the current method, it will take scientists about 4-5 weeks to find immune cells that are expected to treat cancer.
the latest technology to reduce this time to 1 day! The study was reported online today in Cell, a leading academic journal, and Professor Peng Wu of the Scripps Research is the author of the responsible newsletter.
years, the field of cancer immunotherapy has made a significant breakthrough, changing the pattern of cancer treatment.
Whether it's a Nobel Prize-winning immunosupger inhibitor or the on-the-rise tumor-immersed lymphocyte (TIL) therapy, the key lies in tumor-specific T-cells, which either activate tumor-specific T-cells or provide a large number of tumor-specific T-cells from outside the body to attack cancer.
fact, under the immune system, every patient has immune cells that produce tumors, and they are supposed to have excellent cancer treatment.
why do people get cancer when these immune cells are pressed? On the one hand, the number of these immune cells is small;
but it also gives scientists the idea of treating cancer: if we can find these immune cells, amplification them in vitro, and then return them to the patient, won't we have a better chance of treating cancer? The diagram of this study (photo source: Resources) is easier said than done.
these cell surfaces do not have specific markers.
easy to find in the vastness of cells? That's the breakthrough the researchers made in this study.
they developed a method called FucolD, whose name comes from the algae glycosyl transferase.
this approach cleverly exploits the characteristics of the immune system itself: typically, dedritic cells in the immune system present tumor-specific antigens to immune T cells, which are the key cells researchers are looking for.
by this phenomenon, scientists used enzyme-linked methods to add algal glycosyl transferase to the surface of deducination cells.
when these cells meet immune T cells, the enzyme labels the latter as a algal glycosylated biotin.
can find these labels, they can find tumor-specific immune T-cells according to Tussauds. in mouse experiments, researchers at
' cells with special enzymes interacted with tumor-specific T-cells (Photo: Resources 2; Credit: Wu laby at Scripps Research) In mouse experiments, the researchers successfully isolated tumor antigen-specific T-cells from mice, including CD4 or CD8-positive T-cells.
these immune cells usually penetrate the inside of the tumor and attack from the tumor, which is at the heart of cancer immunotherapy.
these cells, which also contribute to subsequent in-body culture and amplification.
for many emerging individualized cancer therapies, the key to success is finding these sometimes hard-to-find T-cells that can directly target tumors.
The simple way to detect and isolate immune cells that respond to tumors can be treated by created more of these cells outside the patient's body and re-delivered back to the patient," said Professor Peng Wu, lead author of the study.
the current high cost of immunotherapy and labor costs, it needs to realize its potential.
I expect that we can further advance the development of individualized immunotherapy.
"At the same time, we can analyze the genetic and metabolic characteristics of these tumor-reactive immune cells to deepen our understanding of how the tumor microenceptic environment affects the function of these immune cells," said Dr. Liu Zilei, co-lead author of the study. Wu Mengxuan, one of the participants in the
study and a professor of oncology at Suzhou University's Annex I Hospital, said: "The clinical application of step-by-step cell immunotherapy for solid tumors is still quite limited, and how to obtain T cells carrying T-cell receptors that identify tumor cells is the key to solving the problem of individualized targeted therapy."
Our approach does a good job of greatly increasing the effectiveness of cell metastasis in solid tumors, and we are preparing to test tumor patient samples in the hope of delivering greater survival benefits to tumor patients."
" researchers point out that by isolating tumor-specific T-cells as quickly as possible, they can be amplified in-body as quickly as possible, treat patients, and doctors can assess the efficacy in the first place.
day is important for patients who are racing against death.
future, scientists will test the feasibility of the technology in human tumor samples and try to apply the platform to human clinical trials.
we look forward to this ingenious technology to realize their potential for the benefit of cancer patients around the world at an early time! References: Zilei Liu et al., (2020) Detecting Tumor Antigen-Specific T Cells via Interaction-Dependent Fucosyl-Biotinylation. Cell Doi: Rapid method of isolating tumor-targeting T cells can propellyed cancer treatments. Retrieved Oct. 23, 2020 from the original title: "Cells": Immune cells for tumors can be found in just 1 day! Professor Wu Peng's team brings new tools for immunotherapy.