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Fibrin Microbeads (FMB) As Biodegradable Carriers for Culturing Cells and for Accelerating Wound Healing

 Last Update: 2020-12-15
 Source: Internet
 Author: User

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Fibrinogen exerts adhesive effects on cultured fibroblasts and other cells. Specifically, fibrin(ogen) and its various lytic fragments (e.g., FPA, FPB, fragments D and E) were shown to be chemotactic to macrophages, human fibroblasts, and endothelial cells (
1
–
3
). Thrombin has also been shown to exert proliferative and adhesive effects on cultured cells (
4
–
7
). We previously demonstrated that covalently coating inert Sepharose beads with either fibrinogen or thrombin rendered them adhesive to a wide range of cell types. We employed such coated Sepharose beads to screen or rank normal and transformed cells for their haptotactic responses to fibrinogen (
8
,
9
).

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