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Recently, Cell Reports published an online research paper titled "The nuclear-localized FGF13 isoform participates in the regulation of neurodevelopment in the hippocampus of postnatal mice through epigenomic mechanisms".
The research was jointly completed by the team of Zhou Jiawei, a researcher at the Chinese Academy of Sciences' Brain Science and Intelligent Technology Innovation Center (Institute of Neuroscience), the Shanghai Center for Brain Science and Brain-like Research, and the State Key Laboratory of Neuroscience, and Hu Gang, a professor at Nanjing Medical University.
The normal development and plasticity of the hippocampus are very important for the establishment of learning and memory in humans and animals after birth.
The hippocampus of mice develops mainly after birth.
The neural stem cells in the lower layer of granulosa cells in the dentate gyrus continue to proliferate and differentiate to produce new neurons, and rapidly expand the size of the hippocampus early in life, participating in the development and plasticity of the hippocampus.
However, this process slows down rapidly around 2 weeks after birth.
Although it can continue into adulthood, the ability of neural stem cells in the dentate gyrus to proliferate and produce new neurons is significantly weakened with age.
The FGF13 gene is a member of the non-secreted fibroblast growth factor subfamily, and is closely related to human sex-linked intellectual developmental disorders and epilepsy, suggesting that FGF13 may play some unknown role in the development of the hippocampus.
Studies have revealed that FGF13B, another variant of FGF13, is an important molecule in the regulation of brain neurodevelopment in the embryonic period of mice.
The study found that the expression level of FGF13 gene in the neural stem cells of the hippocampal dentate gyrus of mice after birth showed a downward trend with the growth of developmental age.
FGF13 gene is an important molecule involved in regulating the development of hippocampal neural stem cells.
Loss of FGF13 gene leads to a decline in the ability of hippocampal neural stem cells to produce new neurons when the mouse is not an adult.
After adulthood, the size of the hippocampal dentate gyrus of the mouse is significantly reduced, and behavioral changes such as decreased learning and memory ability appear.The nuclear localization isoform FGF13A is mainly involved in inhibiting the differentiation of neural stem cells and maintaining the continuous proliferation and expansion of neural stem cells and neural precursor cells.
This effect is to maintain the self-renewal and expansion capabilities of hippocampal neural stem cells by regulating the chromatin remodeling complex protein and changing the open state of cell chromatin (as shown in the figure).
The study revealed the biological functions and molecular mechanisms of fibroblasts located in the nucleus, and provided new clues for in-depth understanding of the developmental disorders of learning and memory in the human brain and the process of neurodegeneration.
The research was completed by Yang Qiaoqiao, a postdoctoral fellow at the Brain Intelligence Center, and his collaborators.
The research work was supported by the academician of the Chinese Academy of Sciences, the Shanghai Institute for Advanced Study of the Chinese Academy of Sciences Zhang Xu, the researcher Yan Jun, and the experimental mouse room, optical imaging platform and molecular cell technology platform of the Center of Excellence for Brain Intelligence.
The research work is supported by the Chinese Academy of Sciences, the Ministry of Science and Technology, the National Natural Science Foundation of China, and the Shanghai Municipal Science and Technology Commission.
FGF13 gene is involved in the regulation of mouse hippocampus development.
The number and neurogenesis ability of FGF13 nuclear localization isoform FGF13A and hippocampal neural stem cells showed a downward trend with the development and age of mice.
FGF13A mainly promotes the self-renewal and proliferation of hippocampal neural stem cells, and inhibits the differentiation of neural stem cells and precursor cells, thereby maintaining the number and ability of expansion of neural stem cells in the lower layer of the granular dentate gyrus during development and aging.
The cytoplasmic localization isoform FGF13B is up-regulated during neural stem cell differentiation, indicating that normal hippocampal development requires the synergistic effect of different isoforms.
Source: Center for Excellence in Brain Science and Intelligent Technology, Chinese Academy of Sciences
The research was jointly completed by the team of Zhou Jiawei, a researcher at the Chinese Academy of Sciences' Brain Science and Intelligent Technology Innovation Center (Institute of Neuroscience), the Shanghai Center for Brain Science and Brain-like Research, and the State Key Laboratory of Neuroscience, and Hu Gang, a professor at Nanjing Medical University.
The normal development and plasticity of the hippocampus are very important for the establishment of learning and memory in humans and animals after birth.
The hippocampus of mice develops mainly after birth.
The neural stem cells in the lower layer of granulosa cells in the dentate gyrus continue to proliferate and differentiate to produce new neurons, and rapidly expand the size of the hippocampus early in life, participating in the development and plasticity of the hippocampus.
However, this process slows down rapidly around 2 weeks after birth.
Although it can continue into adulthood, the ability of neural stem cells in the dentate gyrus to proliferate and produce new neurons is significantly weakened with age.
The FGF13 gene is a member of the non-secreted fibroblast growth factor subfamily, and is closely related to human sex-linked intellectual developmental disorders and epilepsy, suggesting that FGF13 may play some unknown role in the development of the hippocampus.
Studies have revealed that FGF13B, another variant of FGF13, is an important molecule in the regulation of brain neurodevelopment in the embryonic period of mice.
The study found that the expression level of FGF13 gene in the neural stem cells of the hippocampal dentate gyrus of mice after birth showed a downward trend with the growth of developmental age.
FGF13 gene is an important molecule involved in regulating the development of hippocampal neural stem cells.
Loss of FGF13 gene leads to a decline in the ability of hippocampal neural stem cells to produce new neurons when the mouse is not an adult.
After adulthood, the size of the hippocampal dentate gyrus of the mouse is significantly reduced, and behavioral changes such as decreased learning and memory ability appear.The nuclear localization isoform FGF13A is mainly involved in inhibiting the differentiation of neural stem cells and maintaining the continuous proliferation and expansion of neural stem cells and neural precursor cells.
This effect is to maintain the self-renewal and expansion capabilities of hippocampal neural stem cells by regulating the chromatin remodeling complex protein and changing the open state of cell chromatin (as shown in the figure).
The study revealed the biological functions and molecular mechanisms of fibroblasts located in the nucleus, and provided new clues for in-depth understanding of the developmental disorders of learning and memory in the human brain and the process of neurodegeneration.
The research was completed by Yang Qiaoqiao, a postdoctoral fellow at the Brain Intelligence Center, and his collaborators.
The research work was supported by the academician of the Chinese Academy of Sciences, the Shanghai Institute for Advanced Study of the Chinese Academy of Sciences Zhang Xu, the researcher Yan Jun, and the experimental mouse room, optical imaging platform and molecular cell technology platform of the Center of Excellence for Brain Intelligence.
The research work is supported by the Chinese Academy of Sciences, the Ministry of Science and Technology, the National Natural Science Foundation of China, and the Shanghai Municipal Science and Technology Commission.
FGF13 gene is involved in the regulation of mouse hippocampus development.
The number and neurogenesis ability of FGF13 nuclear localization isoform FGF13A and hippocampal neural stem cells showed a downward trend with the development and age of mice.
FGF13A mainly promotes the self-renewal and proliferation of hippocampal neural stem cells, and inhibits the differentiation of neural stem cells and precursor cells, thereby maintaining the number and ability of expansion of neural stem cells in the lower layer of the granular dentate gyrus during development and aging.
The cytoplasmic localization isoform FGF13B is up-regulated during neural stem cell differentiation, indicating that normal hippocampal development requires the synergistic effect of different isoforms.
Source: Center for Excellence in Brain Science and Intelligent Technology, Chinese Academy of Sciences
