Feelings of working in improved new drugs

With the continuous advancement of the national centralized procurement policy, more and more varieties have entered the centralized procurement list.
It is only a matter of time before all drugs enter the centralized procurement list.
Different pharmaceutical companies have faced various countermeasures against this policy.
The same
.

Some small and medium-sized pharmaceutical companies, on the one hand, focus on generic drugs, on the other hand, they are also slowly developing their own innovative drug research and development.
The innovative drugs here also include the hotter improved new drugs
.

(Picture: Network)

The author started to work on improved new drugs in 2019.
I have been doing generic drugs before.
Because the company wants to seek changes, under the pressure of centralized procurement policies, I can’t blindly do generic drugs.
I have also carried out research and development of class 1 new drugs and improved new drugs.
, But the transformation is transformed, the company’s efforts are not strong, and the investment in new drugs is not much, especially the improved new drugs, although compared to the first category of new drugs, the investment in improved new drugs will be more than a billion.
A lot less, and a short time, but it’s a well-established variety, whether its improved variety can replace it, or whether it can take a share of the pie, is unpredictable, unlike the first class of new drugs, it is indeed a real deal.
Money, so although new and improved drugs are very hot, companies need a lot of decision-making power if they want to take root
.

The establishment of an improved new drug project has always been the top priority, and the difficulty is the most difficult.
In addition to having excellent preparation and analysis capabilities, the project applicant needs to cover some clinical, sales, medical and other aspects.
For those of us who have been engaged in generic drugs for a long time For people with abundant generic drug preparation, analysis, and synthesis capabilities, it’s like a punch on cotton.
There is nowhere to do it.
It’s not easy to set up a good and amazing new drug project, even in the industry.
Big coffee is also looking for a needle in a haystack in the establishment of this kind of project.
It is like a headless fly.
There is no practical operation with theory alone.
Large and small forums and salons have participated in a lot, and the gains are minimal, because everyone knows the truth.
To say a thousand words and ten thousand, you have to have the actual improved varieties of new drugs
.

It is not easy to change immediate-release preparations to sustained- and controlled-release preparations, because most of the well-selling varieties, if taken multiple times a day, most of them have been changed by the original manufacturer to the corresponding sustained-released preparations, and the remaining ones Varieties that have not been modified either cannot be modified or they do not sell well.
Therefore, many of them are improved only for improvement.
It is really difficult to impress the reviewing teachers, even us, for improving the compliance of their patients.
The people who set up the project also felt that it was improving for the sake of improvement
.

Here the author briefly introduces a project that is currently underway to change an immediate-release formulation to a sustained- and controlled-release formulation, which is purely an introduction
.

However, improved new drug companies that are determined to make high-end preparations do not have such worries, because technologies such as sustained-release microspheres, liposomes, inhalation preparations, microneedles, etc.
, which were only on the books before, can already be realized, and they will definitely be in the future.
It will sell very well.
In addition to the difficulty and the large investment, you will not worry about selling well after you finish it.
Therefore, these big pharmaceutical companies are also doing things in a hurry, and if there is a variety, it will be enough for the company
.

There are also some companies that have gathered together to make oral dissolving film to improve patient compliance.
Although several varieties have been approved, under the centralized procurement policy, the cost of oral dissolving film will definitely be higher than that of ordinary tablets or capsules.
Oral dissolving film How to enter hospitals, pharmacies, how to deploy companies, how to build their own sales teams, are the problems that companies need to face, and it’s almost a year since the first oral-melting membrane product went on the market.
Is it true? It is also a mystery how it is sold and how it is sold.
I hope that the mouth-melting membrane is not a gimmick.
I hope that some patients will become this batch of leeks and help other patients step on the thunder
.

Some companies target medicines for children.

There are also some companies deploying external preparations, which is also a good starting point.

To sum up, the improved new drug is like a stone thrown into the medical circle by the country.
Although it has caused a wave of ripples, most companies are still testing the water.
Therefore, the improved new drug has a long way to go
.