Featured Project Articles--Application of Non-target Lipidomics Absolute Quantification Plus in Lipidomics

Lipids are essential components of cell membrane structure and play important roles in many cellular processes, including cell growth, proliferation, differentiation, and signaling

Zhongke New Life's non-target lipidomic products have been heavily upgraded to non-target lipidomic absolute quantification plus, which has five major characteristics:

1.

Article title: Degradation of lipid droplets by chimeric autophagy-tethering

https://mp.

2.

Article title: Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion

3.

Title of the article: A small molecule targeting ALOX12-ACC1 ameliorates nonalcoholic steatohepatitis in mice and macaques

4.

Article title: Cadmium exposure impairs pancreatic β-cell function and exaggerates diabetes by disrupting lipid metabolism

5.

Article title: Lipid reprogramming induced by the TFEB-ERRα axis enhanced membrane fluidity to promote EC progression

6.

Title of the article: Investigation of oyster Crassostrea gigas lipid profile from three sea areas of China based on non-targeted lipidomics for their geographic region traceability

7.
Lipidomics technology facilitates plant stress research

Title: Silencing of Sulfoquinovosyl Diacylglycerol Synthase 1 Impairs the Glycolipids Accumulation and Photosynthesis in Phosphate-deprived Rice
Impact Factor: 7.
298
Published Journal: Journal of Experimental Botany
Published: 2021.
6 Cooperative unit: Shanghai Academyof
Agricultural Sciences Omics: Lipidome Research CONCLUSIONS: Analysis of the concentrations of different lipid species in glucosyl diacylglycerol synthase 1 (OsSQD1) mutants shows that under Pi deficiency, OsSQD1 silencing leads to an increase in phospholipids and a decrease in glycolipids, and altered fatty acids composition .
Furthermore, OsSQD1 silencing also inhibited photosynthesis by downregulating glycolipids in rice seedlings .
Studies have shown that OsSQD1 plays a key role in lipid homeostasis, especially the accumulation of glycolipids upon Pi deficiency .
Article interpretation link: https://mp.
weixin.
qq.
com/s/WmizjVMMAqPQOWEzOuHVrA  

8.
Lipidomics technology facilitates the study of mitochondrial lipid changes in early post-mortem beef

Title of the article: Alteration of Mitochondrial Lipidome and Its Potential Effect on
Apoptosis, Mitochondrial Reactive Oxygen Species Production, and Muscle Oxidation in Beef during Early Postmortem
Impact Factor: 5.
895
Published Journal: Journal of Agricultural and Food Chemistry
Published Date: 2022.
6
Partner: China Agriculture University
Omics Approach: Lipidome
Conclusions: This study investigated changes in mitochondrial lipid molecules in the early postmortem period and their potential impact on mitochondrial ROS generation and muscle oxidation
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It was found that mitochondrial lipids changed significantly (1−24 h) postmortem and also differed among different muscle types, and the levels of apoptosis-related lipid molecules increased in the early postmortem and promoted apoptosis
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Lipid molecules can assist the production of mitochondrial ROS, reduce mitochondrial membrane potential (MMP) during postmortem apoptosis, and lead to muscle oxidative and antioxidant system damage
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The above is just a brief sharing of several client literatures of Zhongke Xinsheng Lipidomics.
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