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A study involving oxidant amplification loops led by Marshall University scientists showed that the results published this week revealed the role of fat cells in cognitive decline and neurodegeneration
The study, published in the journal Science, showed that fat cells control the systemic response to brain function, leading to impaired memory and cognitive functions in mice
"Our goal is to prove that Na, k-atp enzyme signaling, especially in fat cells, plays a central role in inducing changes in specific areas of the brain, especially in the hippocampus, which is essential for memory and cognitive functions.
The researchers used a genetically modified mouse model to specifically release the peptide NaKtide in adipocytes or adipocytes, and found that NaKtide inhibits the signal function of Na and k-atp enzymes
"Western diet induces oxidative stress and fat cell changes through Na and k-atp enzyme signals, leading to systemic inflammation, affecting behavior and biochemical changes in the brain," the first author, Komal Sodhi, associate professor of surgery and biomedicine at Joan C.
DOI
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