Fat can destroy three generations! Obesity in mothers increases the risk of liver cancer in future generations.

About one third of the world's population is overweight or obese. This global obesity disease is threatening human health.studies have shown that obesity increases the risk of metabolic diseases such as nonalcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC).in the United States, up to 50% of newly diagnosed HCC are the result of abnormal liver metabolism.researchers realized that there was a link between maternal obesity and the risk of liver cancer in offspring, but the mechanism was not clear.recently, the Journal of In a new study published in Hepatology, a team led by Professor Zheng Ling, chief researcher of School of life sciences, Wuhan University, and Professor Huang Kun, affiliated Tongji School of pharmacy, Tongji Medical College, Huazhong University of science and technology, found that a microRNA in the mothers of obese mice seemed to be susceptible to liver cancer, thus increasing the possibility of their offspring and offspring suffering from liver cancer.doi: specifically, in order to study this issue more carefully in the context of maternal obesity and the risk of HCC in the background, researchers gave diethylnitrosamine (DEN) to induce liver cancer in obese mice fed a high-fat diet.RNA sequencing was performed to identify genes and microRNAs that changed with generation.the results showed that microRNA mir-27a-3p injected into pregnant mice not only increased the content of mir-27a-3p in liver, but also decreased the expression of ACSL1 and ALDH2 genes in offspring (fetal, juvenile and adult) and aggravated the development of HCC in den treated offspring.that is to say, maternal obesity induced by high-fat diet causes the susceptibility of offspring to den induced HCC.the researchers determined that this susceptibility was cumulative over generations.in addition, the incidence of liver cancer increases between two generations.for example, offspring of obese mothers and grandmothers are more severe than offspring of grandmothers of obese mothers but of normal weight.in addition, the researchers analyzed human liver cancer samples, including 27 fatty liver related HCC and 27 non fatty liver related HCC. The results showed that mir-27a-3p was negatively correlated with ascl1 and ALDH2 in HCC patients with or without fatty liver disease.Professor Zheng Ling said that maternal obesity directly affects the health of offspring and plays an important role in the prevalence of obesity and metabolic diseases.Professor Huang Kun said that epidemiological studies have shown that obesity is an independent risk factor for liver cancer.our research provides insights into whether maternal obesity is and whether it affects the incidence rate of cancer in future generations.in the accompanying editorial, Dr. Sabine Colnot of the Cordeliers research center in Paris, France, and Dr. Andr é lechel, hospital hospital hospital of Ulm University in Germany, commented that "this study opens up a new approach to metabolism and epigenetics for cancer research. it brings new information on how maternal obesity affects the development of liver cancer in their offspring. "the researchers also pointed out that there are still unknowns in this new study, including the genetic mechanism of mir-27a-3p. in addition, whether the findings in mice can be directly applied to humans. these questions still need further research. in conclusion, since maternal obesity is an independent factor leading to metabolic diseases in offspring, and liver cancer is closely related to metabolic diseases, this animal study reveals the mechanism of maternal obesity and cancer development in offspring. further clinical and epidemiological investigations will help to link the findings in humans, and attention should be paid to the potential clinical effects of intergenerational and multigenerational phenomena. the so-called three generations are poor, three generations are rich, and three generations are destroyed by obesity. for the health of the offspring, move. end References: [1] material oxygen increases the chance of liver cancer in offspring for generations [2] microRNA in obese mothers, grandmothers passes increased liver cancer risk to multiple generations of offspring