Famous people are getting better and better, riding on the momentum, gathering momentum and strengthening, advancing the lymphoma diagnosis and treatment center of Zheng Dayi Affiliated Hospital

Inheriting the thousand-year-old cultural context, concentrating the essence of the original, and the profound cultural heritage, the First Affiliated Hospital of Zhengzhou University (hereinafter referred to as the "First Affiliated Hospital of Zhengzhou University") and the lymphoma diagnosis and treatment center have the spirit of erudition, professional innovation and the character of pragmatism and hard work, unity and progress
.
Over the years, under the leadership of Professor Zhang Mingzhi and Professor Zhang Lei, the lymphoma team has adhered to the original intention of "health department, life trust", down-to-earth, step up, from a few beds to two wards, and then from the hospital lymphoma diagnosis and treatment center to Henan Province lymphoma diagnosis and treatment center, they continue to develop and grow, and gradually reach the international leading level
.

In 2022, the special column of "Famous Artists Heal Sound - China Lymphoma Benchmarking Pilot Hospital Series Report" will share the growth path and diagnosis and treatment management characteristics of lymphoma specialties by domestic benchmark hospitals, aiming to further improve the level of lymphoma diagnosis and treatment and help the development of
lymphoma diagnosis and treatment.
In this issue of "Famous Artists Grow Sound", we walk into the lymphoma specialist team
of Zhengda First Affiliated Hospital.

Accumulate trickles into rivers and seas, gathering wisdom to cure all troubles

"The establishment of Henan Lymphoma Diagnosis and Treatment Center is conducive to improving the understanding of lymphoma among the majority of medical care, so as to better serve the majority of lymphoma patients
.
"

- Professor Zhang Mingming

"It has been 14 years since the establishment of our center, and we have grown from 3 or 4 doctors to more than 30 doctors now, and we are constantly moving forward and making a lot of achievements
.
"

——Professor Zhang Lei

As early as 1993, Professor Zhang Mingming began to carry out research on the diagnosis and treatment of lymphoma; In 2008, the lymphoma ward - the five wards of the oncology department were established; In 2009, with the approval of the Provincial Department of Health, Henan Lymphoma Diagnosis and Treatment Center
was established.

Henan Lymphoma Diagnosis and Treatment Center relies on the Lymphoma Center of Zhengda First Affiliated Hospital, with the five wards of the oncology department of Hehe Hospital District and the three wards of the oncology department of Huiji Hospital District as the main body, and is composed of
multidisciplinary experts such as pathology, hematology, radiotherapy, imaging, stem cell transplantation center, and blood cell laboratory.

In recent years, under the leadership of Professor Zhang Mingming and Professor Zhang Lei, the lymphoma diagnosis and treatment center has developed rapidly and the team has continued to grow, and now it has become a high-level and innovative professional team
with 30 doctors and 43 nursing staff.

Group photo of the team of the Lymphoma Diagnosis and Treatment Center of Zheng University First Affiliated Hospital

At present, there are 110 beds in the two wards and 9 laminar flow beds
.
With the continuous improvement of diagnosis and treatment, the number of lymphoma patients admitted to the treatment has increased year by year, with nearly 7,500 patients admitted to the lymphoma team and nearly 2,100 new lymphoma patients admitted in 2021
.
Professor Zhang Lei introduced that the Lymphoma Diagnosis and Treatment Center of Zhengda First Affiliated Hospital has progressed in exploration, and has gradually formed a perfect theoretical system, advanced technical methods and unique diagnosis and treatment characteristics, which can diagnose and treat
difficult, critical, elderly and refractory lymphomas.
At the same time, it has also made many achievements in academia and issued a strong voice
of China internationally.

Clinical and scientific research promote each other, and the nine characteristics are internationally renowned

"Over the years, Professor Zhang Mingmingzhi has led our team to make great strides, achieved many achievements, and even some aspects have a certain influence
in the world.
"

——Professor Zhang Lei

Lymphoma clinics admit patients to almost all lymphoma subtypes, with diffuse large B-cell lymphoma (DLBCL) and NK/T-cell lymphoma in the top two
groups.
NK/T-cell lymphoma is a highly heterogeneous lymphoma, which is currently a treatment problem in the world, and the clinical diagnosis and treatment and basic research of NK/T-cell lymphoma of the Lymphoma Diagnosis and Treatment Center of Zhengda First Affiliated Hospital are at the international leading level
.

Professor Fu Xiaorui introduced that after long-term efforts, the lymphoma team of Zhengda First Affiliated Hospital has formed nine major diagnosis and treatment characteristics: NK/T-cell lymphoma, gastric lymphoma, primary central nervous system lymphoma, geriatric lymphoma, peripheral T-cell lymphoma, lymphoma with hemophagocytic syndrome, lymphoma hematopoietic stem cell transplantation, fever to be diagnosed and differentiated, and CAR-T cell therapy
。 Professor Zhang Lei pointed out that the backbone members of the diagnosis and treatment center are responsible for different clinical and scientific research directions, and everyone has a division of labor and cooperation, and collaborates to do clinical and scientific research work collaboratively and efficiently
.

In terms of scientific research, the lymphoma diagnosis and treatment center has undertaken more than 30 national, provincial and municipal research projects, including more than 20 national natural science foundations, won 5 national and provincial scientific progress awards, and the team has published more than 340 academic papers, more than 160 Chinese articles, and more than 180 SCI articles in recent years, and some research results have been published in JAMA Oncology, Blood, Nature Communications, and Clinical Cancer Research, Leukemia and other internationally renowned journals
.

Lymphoma team publishes SCI papers

The DDGP chemotherapy regimen pioneered by the team was included in the 2020 NCCN guidelines, becoming one of
the preferred first-line regimens recommended by authoritative international guidelines for the treatment of NK/T-cell lymphoma.
The relevant results were rated as "Top Ten Lymphoma Research Progress in 2019" by the Oncology Branch of the Chinese Medical Association, and Professor Zhang Mingming was invited to give an oral presentation
at the international conference.

Deepen exchanges abroad and at home to promote common development

"In the in-depth exchanges with colleagues at home and abroad, it has also driven the development of
our team as a whole.
"

——Professor Zhang Lei

It is difficult for the lone to rise, but easy for the multiplier
.
The Lymphoma Diagnosis and Treatment Center of Zhengda First Affiliated Hospital attaches great importance to exchanges and cooperation
at home and abroad.
Internationally, it has successively conducted study visits with Mayo Clinic Lymphoma Center, Anderson Cancer Center, Duke University Hematology Cancer Center, Columbia University Cancer Center, University of Pittsburgh UPMC, Hopkins University Cancer Center, University of Oslo Cancer Center in Norway, and Heidelberg University Lymphoma Center in Germany.
It has established long-term friendly cooperative relations in the international community
.

Foreign experts visit and exchange photos

In China, the Lymphoma Diagnosis and Treatment Center of Zhengda First Affiliated Hospital actively hosts or participates in academic activities to promote the standardized diagnosis and treatment of regional lymphoma and promote common development
.
It has hosted various forms of large-scale academic activities such as the Lymphoma Summit Forum and CSCO Anti-Lymphoma Alliance Tour (14th sessions), the Central Plains Cancer Integrated Medical Summit Forum and the Henan Provincial Medical Doctor Association Oncologist Annual Conference (a total of 9 sessions), the National Lymphoma Standardized Diagnosis and Treatment and Progress Study Class and the "Zhihui Zhongyuan" Lymphoma College (a total of 2 sessions), and representatives from all over the country went to the Lymphoma Diagnosis and Treatment Center of Zhengda First Affiliated Hospital to observe and learn, promote each other and develop
together in exchanges.

Photos of some academic conferences

Doctors and nurses work together to promote standardized diagnosis and treatment

"Whether it's MDT or collaboration with the care team, we try to be as granular as possible
.
"

——Professor Zhang Lei

In addition to large-scale academic activities, the Lymphoma Diagnosis and Treatment Center of Zhengda First Affiliated Hospital holds MDT academic activities every 2-4 weeks, with the participation of personnel from relevant departments inside and outside the province, such as oncology, pathology, radiotherapy, laboratory medicine, and imaging, and the format of the conference includes special lectures, case discussions, consultation of difficult cases and scientific research collaboration
.
Since the establishment of the lymphoma diagnosis and treatment center, nearly 150 MDT consultation activities have been held, and more than 3,000 difficult cases have been consulted inside and outside the province
.

MDT Academic Consultation Activities

In daily clinical work, the MDT team gives full play to synergy, such as early docking with the pathology department when patients are treated, and guiding patients to achieve a clear diagnosis; In the expert outpatient clinic, the MDT team participates in the diagnosis and treatment of patients with difficult lymphoma and promotes standardized diagnosis and treatment
.

Nurse Dong Lei mentioned, "Our two professors Zhang proposed the concept of 'medical and nursing integration', so that the nursing team can participate more in clinical work and have more exchanges
with the medical team in terms of professional knowledge.
"In the work, the nursing team will work with the doctors to conduct professional training, ward rounds, consultations, free consultations, etc.
, and provide more professional services
for patients.

Healthcare integration

The whole process of management inside and outside the hospital protects the long-term cure

"It is of great significance to promote whole-process management in an orderly manner and standardize and standardize diagnosis and treatment for patients, and I hope that the road of whole-process management will go further and further
.
"

- Professor Zhang Mingming

The concept and significance of the whole process management of lymphoma

Dong Lei, head nurse, introduced that the release of the "Expert Consensus on the Whole Management Model of Lymphoma Patients in China" has greatly promoted the implementation of the whole management model of lymphoma diagnosis and treatment centers
.

The whole process management of lymphoma diagnosis and treatment center mainly includes three parts: pre-hospital guidance, standardized diagnosis and treatment during hospitalization and follow-up after discharge, that is, comprehensive guidance before admission, connecting multiple disciplines, and guiding patients into the correct department; One-to-one all-round tracking of patients during hospitalization, solve patients' doubts in diagnosis and treatment, and achieve all-round care; Standardized long-term follow-up and management
after discharge.

Professor Li Xin introduced that especially for some incurable and long-lasting indolent lymphomas, such as follicular lymphoma (FL), long-term management of patients after discharge is particularly important
.
WITH THE DOMESTIC MARKETING AND MEDICAL INSURANCE LANDING, OBINUTUZUMAB HAS BEEN WIDELY USED IN FL PATIENTS, AND OCTINUTUZUMAB COMBINED WITH CHEMOTHERAPY SEQUENTIAL MONOTHERAPY MAINTENANCE THERAPY IS THE NEW STANDARD REGIMEN FOR FIRST-LINE TREATMENT OF FLO, WHICH IS MAINLY BASED ON GALLIUM RESEARCH
.
THE GALLIUM STUDY SHOWED THAT THE G-CHEMOTHERAPY REGIMEN SIGNIFICANTLY IMPROVED PROGRESSION-FREE SURVIVAL (PFS) (3-YEAR PFS RATE 80.
0% VS 73.
3%, HR=0.
66, P=0.
001), REDUCED THE RISK OF PROGRESSION, RECURRENCE, OR DEATH BY 34%, AND EARLY PROGRESSION (POD24) BY 46%
IN PATIENTS WITH TREATMENT-NAÏVE FLO 。 Professor Zhang Xudong said that the standardized use of obinutuzumab in full dose and full course can help patients achieve better efficacy, and the department usually infuses 1000mg of fixed dose of obinutuzumab on the 1, 8 and 15 days of the first cycle of induction therapy, and carries out induction therapy for 6 or 8 cycles according to the chemotherapy regimen, and then sequential obinutuzumab monotherapy for 2 years, once every 2 months
.
Professor Li Ling pointed out that patients have a long medication time in treatment, and long-term management can help patients improve treatment compliance, so as to standardize the completion of full course of treatment and enable patients to obtain more survival benefits
.

Rich content of patient education

In addition, Professor Zhang Lei introduced that the science education for patients also runs through the whole process of treatment, and the lymphoma diagnosis and treatment center manages patients through online and offline channels inside and outside the hospital, including outpatient clinics, public areas of the ward to place lymphoma disease science leaflets, play popular science videos, regularly carry out ward patient churches, cure patient sharing meetings, World Lymphoma Publicity Day patient education activities, etc
。 The experts of the lymphoma team keep pace with the times, carry out online popular science lectures, shoot short popular science videos, build popular science public accounts, form patient groups, etc.
, maintain multi-faceted communication with patients, answer patients' questions, and further improve the awareness of patients and their families about lymphoma diseases, so as to better cooperate with treatment and better manage diseases
.

Full management provides more comprehensive services and better management
for the diagnosis and treatment of lymphoma patients.

postscript

Those who do are always successful, and those who walk are always there
.
From 0 to 1, from 1 to N, the lymphoma team of Zhengda First Affiliated Hospital has gone through 14 years, every step has been firm and steadfast, they always keep in mind that "health is related, life is trusted", continue to promote the standardized diagnosis and treatment of lymphoma, and serve patients with professional and innovative diagnosis and treatment, and continue to move forward towards the goal of curing lymphoma!

Prof.
Zhang Mingming

Doctoral supervisor, director of Cancer Center of the First Affiliated Hospital of Zhengzhou University

Member of the Standing Committee of the Oncology Branch of the Chinese Medical Association

Professor Zhang Lei

Ph.
D.
, postdoctoral fellow, chief physician, professor, master supervisor, deputy director of the Department of Medical Oncology, Director of Lymphoma Ward, Deputy Director of Henan Lymphoma Diagnosis and Treatment Center, Deputy Director of the First Affiliated Hospital of Zhengzhou University

Member of the Standing Committee of the Clinical Hematology and Lymphatic Professional Committee of the Chinese Association of Women Physicians