Failure to absorb manganese effectively can lead to scolios in children

a new U.S. study says the body's inability to make effective use of manganese in the diet due to genetic mutations may cause scoliotic convexity in children.
Researchers at Washington University School of Medicine in St. Louis reported that their study showed that children with severe scoliotic scolios were twice as likely to develop a genetic mutation that makes it difficult for cells to ingest and utilize manganese, which is associated with bone growth.
scoliosis, commonly known as scoliosis, is a three-dimensional malformation of the spine, mild scoliosis usually has no obvious symptoms, heavy time will affect the growth and development of adolescents and children, so that the body deformation, serious can affect cardiopulmonary function, and even tired spinal cord. The pathogenesis of scolios in children is not clear.
team genetically tested 457 children with severe scolios and 987 children in the control group. It was found that the proportion of mutations in healthy children called the SLC39A8 gene was 6%, while the proportion of mutations in children with severe scolios was 12%.
also conducted genetic analysis on 841 other children with different degrees of scolios and 1,095 healthy children. The results also showed that the previous group had twice as many mutations in the gene as the 13th group.
researchers also bred zebrafish with these genetic defects, which show movement and bone abnormalities, including scolio convexities.
previously studied the SLC39A8 gene, but some studies say it helps cells absorb zinc, iron and manganese. New research has found that after this gene mutation, the body can still absorb zinc and iron normally, but can not absorb manganese. Children with this genetic mutation have significantly lower levels of manganese in their blood, although they are still within the normal range.
research paper is published in the new issue of the British journal Nature Communications. The study linked a common disease to controlled dietary factors, said senior author Christina Ghnett, a professor at Washington University School of Medicine in St. Louis. But Ghneit also said people should not blindly replenish manganese, because excess manganese is harmful to the body. (Source: Xinhua News Agency, Zhou Zhou)