Express uses red blood cells to extensively stimulate the immune system, and innovative anti-cancer therapy enters the clinic

▎WuXi AppTec Content Team Editor On January 13, 2022, Rubius Therapeutics announced that its Phase 1/2 clinical trial of RTX-224, a red blood cell therapy designed to broadly stimulate the immune system, has completed the first patient dosing for For the treatment of certain patients with relapsed/refractory or locally advanced solid tumors, including non-small cell lung cancer, cutaneous melanoma, head and neck squamous cell carcinoma, urothelial (bladder) cancer, and triple-negative breast cancer
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 Rubius aims to bioengineer red blood cells to create an entirely new class of cellular drugs for the treatment of cancer and autoimmune diseases
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RTX-224 is an allogeneic red blood cell therapy engineered to express 4-1BBL and IL-12 that activates CD4-positive, CD8-positive T cells, and natural killer (NK) cells by stimulating the 4-1BB and IL-12 pathways and antigen-presenting cells (APCs) to generate robust anti-tumor immune responses
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Image source: Rubius' official website This open-label, multi-center, multi-dose dose-escalation and expansion Phase 1/2 clinical trial aims to determine the efficacy of RTX-224 in certain adult patients with relapsed/refractory or locally advanced solid tumors Safety, tolerability, pharmacokinetics, maximum tolerated dose, and recommended Phase 2 dose and dosing schedule
in
The trial will also assess pharmacodynamic changes from baseline in immune cell populations, and antitumor activity
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"We expect RTX-224 to generate broad and robust antitumor T cell responses and innate immune responses, showing anticancer activity in tumors sensitive to T cell killing
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"Given RTX-224's mechanism of action and the comprehensive preclinical data we have obtained to date, we believe that RTX-224 has the potential to be a promising candidate for certain advanced solid tumors.
" effective treatment
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"Reference: [1] Rubius Therapeutics Announces Dosing of First Patient in Phase 1/2 Trial of RTX-224, a Broad Immune Agonist, for the Treatment of Certain Solid Tumors.
Retrieved January 13, 2022, from https://ir .
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