Express treatment of solid tumors, TCR cell therapy with stem cell characteristics enters the clinic

▎WuXi AppTec Content Team Editor On January 24, 2022, Lyell Immunopharma announced that the U.
S.
FDA has approved the IND application for a Phase 1 clinical trial of the investigational T cell receptor (TCR) therapy LYL132 for the treatment of New York esophageal squamous cell carcinoma patients with solid tumors with neoplasm 1 (NY-ESO-1) antigen
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NY-ESO-1 is a cancer testis antigen (CTA) expressed in a variety of solid tumors but rarely in normal tissues
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The therapy is currently being co-developed by Lyell and GlaxoSmithKline (GSK)
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According to the press release, the Phase 1 clinical trial will evaluate the efficacy and safety of LYL132 in patients with advanced synovial sarcoma (SS) and myxoid/round cell liposarcoma (MRCLS) expressing NY-ESO-1, and Lyell is responsible for the manufacture of the therapy.
, GlaxoSmithKline will be responsible for conducting clinical trials
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 NY-ESO-1 is a member of the CTA family of tumor-associated antigens and is a clinically validated therapeutic target that is highly expressed in various solid tumor types, including non-small cell lung cancer, bladder cancer, SS, and MRCLS
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SS is a rare malignant tumor of soft tissue, accounting for approximately 5-10% of all soft tissue sarcomas
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Patients often develop cancer metastasis, especially lung metastasis, resulting in a 10-year survival rate of less than 50%
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One of the most common types of liposarcoma, accounting for about 30 percent of all cases, MRCLS is a rare soft connective tissue tumor that grows in the body's fat-storing cells, usually in the arms and legs
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When cancer metastasis occurs, the 5-year survival rate of patients is about 40%
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LYL132 incorporates Lyell's ex vivo epigenetic reprogramming technology, Epi-R
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This technology is designed to overcome a major obstacle to adoptive T cell therapy by generating T cell populations with durable stem cell properties to achieve clinically meaningful and long-term clinical responses
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Persistent stem cell characteristics are the ability of T cells to persist, self-renew and proliferate while maintaining anticancer effects
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▲Dr.
Rick Klausner shared his insights on cell therapy development at the 2020 WuXi AppTec Global Forum Related reading: Farewell to the "Stone Age" of Cell Therapy | Dr.
Rick Klausner, Chairman of the Lyell Board of Directors of WuXi AppTec Global Forum, said: The clinical evaluation of the potential benefits of reprogrammed T cells with durable stem cell properties is an important and exciting milestone for Lyell and cancer drug development
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We believe that T cells lacking durable stem cell properties are an ACT therapy A major barrier to solid tumors, and expect our Epi-R technology platform to provide patients with a path to better clinical outcomes
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"Reference: [1] Lyell Immunopharma Announces FDA Clearance of IND for LYL132, a T-Cell Receptor Therapy for Solid Tumors Being Developed in Collaboration with GSK.
Retrieved January 24, 2022, from https:// news-release/2022/01/24/2371644/0/en/Lyell-Immunopharma-Announces-FDA-Clearance-of-IND-for-LYL132-aT-Cell-Receptor-Therapy-for-Solid-Tumors-Being- Developed-in-Collaboration-with-GSK.
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