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Express Disease control rate 100%! The combination of KRAS inhibitors in the treatment of colorectal cancer yielded positive results

 Last Update: 2022-09-14
 Source: Internet
 Author: User

▎ WuXi AppTec content team editor

Mirati Therapeutics today announced the results

Adagrasib is a highly specific, powerful oral KRAS G12C inhibitor optimized for long-lasting target inhibition

The analysis included 44 patients receiving adagrasib monotherapy and 36 patients treated with a combination of adagrasib/cetuximab, with median follow-up times of 20.

▲ Design features of Adagrasib (Image source: Mirati official website)

In 43 assessable adagrasib monotherapy patients, investigators assessed a confirmed objective response rate (ORR) of 19% (8/43), a disease control rate of 86%, a median duration of remission (DoR) of 4.

Among the 28 patients treated with evaluatable combination therapies, the ORR was 46%, the disease control rate was 100%, the median DoR was 7.

In terms of safety, adagrasib monotherapy and combination therapy showed good tolerance, most treatment-related adverse events were grade 1-2, and no patients died

"These exciting results further deepen our understanding

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