Exploration Miraculous "Nano-Neurotrophic Factor" Blocks Nerve Injury-Alcoholism

Alcoholism will reduce or lose one’s ability to control self-control, leading to severe learning, cognitive and behavioral obstacles, and even worse, committing illegal and criminal behaviors
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In terms of mechanism, alcohol abuse can cause cell metabolism, synaptic plasticity, and neurotransmitter transmission, and other neuronal functions, and ultimately lead to central nervous system disease
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In order to solve this cutting-edge problem related to society, the research group of Xue Xue from the State Key Laboratory of Medicinal Chemistry and Biology of Nankai University and the research group of Professor Wu Chunfu/Yang Jingyu of the School of Pharmacy of Shenyang Pharmaceutical University started from single-walled carbon nanotubes (single-walled carbon nanotubes).
, SWNTs) have been steadily screened for the most effective ingredients.
Through the study of the therapeutic effects and mechanisms in vivo and in vitro, a low-dose long-term recovery of the learning and cognitive ability of ethanol rats has been explored, neuronal damage is repaired, and neurons are promoted.
The regenerated "nano-neurotrophic factor" provides a new strategy for the treatment of central nervous system diseases
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The author prepared and screened SWNTs with different characterizations, and through Morris water maze and new object discrimination experiments, it was found that SWNTs (bSWNTs) exhibiting tube bundle morphology can significantly reverse the cognitive impairment caused by ethanol in rats
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Then, the authors found through transmission electron microscopy, immunofluorescence and other techniques that bSWNTs can significantly reverse the abnormal synaptic morphology and neuronal axon abnormalities caused by ethanol, and at the same time promote the neurogenesis level in the hippocampus; the results of gene chip analysis suggest that bSWNTs can significantly Activate MAPK, AKT and other signal pathways
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The authors further discovered through the fluorescence energy resonance transfer technology that bSWNTs can bind to the receptor tyrosine kinase receptor B (TrkB) of BDNF and promote its phosphorylation, thereby mimicking BDNF
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Finally, in order to further verify the exact target of the role of bSWNT in reversing ethanol-induced nerve damage and memory impairment in rats, the authors constructed a shRNA AAV vector targeting TrkB and finally found that the hippocampus-specific knockdown of TrkB expression can significantly inhibit bSWNTs.
Role
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In summary, this thesis systematically evaluated the effect of carbon nanotubes on the improvement of central nervous system damage caused by ethanol in combination with experimental techniques such as materials science and pharmacology, and clarified the relevant regulatory mechanism of the interaction between bSWNT and TrkB, which is used to treat ethanol-induced Nerve injury provides new treatment ideas and treatment strategies
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At present, relevant research results have been published in Exploration.
Researcher Xue Xue of Nankai University and Professor Chunfu Wu of Shenyang Pharmaceutical University are the corresponding authors of the paper.
Support for the key research and development plan (2018YFA0209800)
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The content of this article is based on the "Receptor-targeting nanomaterials alleviate binge drinking-induced neurodegeneration as artificial neurotrophins" published in the Research Article in the first issue of the first volume of the Wiley Publishing Group's cooperative journal Exploration DOI: 10.
1002/EXP.
20210004 Quote format: J.
Yang, L.
Wang, L.
Huang, X.
Che, Z.
Zhang, C.
Wang, L.
Bai, P.
Liu, Y.
Zhao, X.
Hu, B.
Shi, Y.
Shen, X.
-J.
Liang, C.
Wu, X.
Xue, Exploration 2021, 1, 61–74.
https://doi.
org/10.
1002/EXP.
20210004END Journal introduction Scan the QR code | Follow Journal Exploration by Henan University, China Sponsored by the Nanobiology Branch of the Biophysical Society, published by Wiley Publishing Group, with Professor Liang Xingjie as the chief editor and Professor Shi Bingyang as the executive editor
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