Explanation of compulsive feeding behaviors induced by excitatory neurons in the anterior pervetic nucleus of the hypothalamic nucleus in high-fat diets

On August 1, 2022, the team of Yudong Zhou/Yi Shen of the School of Brain Science and Brain Medicine of Zhejiang University revealed that a high-fat diet can cause abnormal proliferation of microglia in the anterior subthalamic nucleus, and activate excitatory neurons in this area, inducing compulsive eating behavior

In 2018, the team published an article in frontiers in Molecular Neuroscience magazine, Anterior Paraventricular Thalamus to Nucleus Accumbens Projection Is Involved in Feeding Behavior in a Novel Environment It was revealed that the circuit regulation novelty inhibition of feeding behavior by glutamatergic neurons of the paraventricular nucleus of the thalamus to the nucleus accumbens was revealed, and the feeding behavior

1.

The researchers trained the mice to receive a reward of 10 percent sucrose solution after the bar press, and as the number of trainings increased, the number of mouse levers increased

Immunofluorescence experiments found a significant increase in the number of neurons activated in the aPVT region of mice on a high-fat diet compared with normal mice, and most of them were excitatory neurons, and there was no such difference in the posterior part of the paraventricular nucleus of the thalamus

Fiber optic calcium imaging technology found that mice did not cause changes in excitatory neuronal activity in the aPVT region during the process of pressure rod or plantar shock alone, but the excitatory neuronal activity of the aPVT region of mice with a fat diet during the pressure rod process under the light cue of risking electric shock was significantly increased

Further optogenetic techniques can further promote mice to risk electric shock to perform pressure bar experiments to obtain aqueous sugar solutions

Figure 1: APVT region excitatory neurons in high-fat diet mice are activated in large quantities

2.

Compulsive eating induced by a high-fat diet

Studies have shown that high-fat diet-induced inflammation of the hypothalamus occurs simultaneously with microglia activation, characterized by rapid changes in

Mice on a high-fat diet have an increased number of microglia in the aPVT region and are in close contact

Figure 2: A high-fat diet promotes abnormal proliferation of microglia in the aPVT region

summary

This paper reveals that anterior excitatory neurons in the paraventricular nucleus of the thalamus play an important role

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