Experts have found that a protein derived from Helicobacter pylori can cause cancer
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Last Update: 2020-07-05
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Source: Internet
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Author: User
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a team of researchers at Hokkaido University in Japan haveby animal experiments thata protein called CagA, which invades the stomach, causes cancer,the study could help people understand the pathogenesis of stomach cancerComprehensive local media reported on the 8th,previous studies have shown that,Helicobacter bacteria infected stomach mucosa cells, will inject the cell into the "CagA" proteinExperts from Hokkaido University's Institute for Geneticdiseasecontrol obtained the gene for the synthetic "CagA" protein from Helicobacter pylori and implanted it in fertilized eggs in laboratory mice to see how the "CagA" protein was synthesized later on the newborn miceObservations showed that in about200of young mice, more than half of the stomach mucosa cells proliferated within 3 months of birth, the stomach wall thickened, and then about2
0 young mice had gastric polyps Within a year and a half, 2
of these laboratory mice had stomach cancer, four had small bowel cancer and more than 10 had leukemia symptoms In previous experiments on some of the cultured cells, experts have found that the "CagA" protein binds to another protein, SHP-
2
, in the cultured cells, causing cell carcinoma The team concluded that finding ways to inhibit the activity of the "CagA" protein, or prevent its binding with the "SHP-
2
protein, could prevent cancer The results will be published online this week in the Proceedings of the National Academy of Sciences
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