The transmission chain of the delta mutant strain of the new crown virus that started at Nanjing Lukou International Airport is still spreading
The new crown vaccine that most people in our country vaccinate is an inactivated new crown vaccine that adopts a two-shot immunization program
On July 29, a number of experts in an interview with The Paper ( proposed that some key populations should be vaccinated with a third dose of vaccine to boost immunity
Why propose to strengthen the third needle?
Why propose to strengthen the third needle? The level of neutralizing antibody is an important indicator for evaluating the protective efficacy of the new crown vaccine
"This situation is not ideal, and it is not good for epidemic prevention and control
Hongkong "If a cluster of infections still occurs after the vaccine is vaccinated, there will still be one transmission and ten transmissions.
Jin Dongyan believes that foreign countries have already implemented the new crown vaccine booster injection for some people, and this issue should also be considered in China
According to sources the British Ministry of Health issued June 30, the government of independent experts "vaccination and immunization joint committee would" recommend the outbreak started in September is the most vulnerable populations hit third dose booster shot, in order to strengthen before this winter Protection of this part of the population
Committee member But the British Ministry of Health also said that with the ongoing data analysis, the committee will be final recommendations are subject to change
Committee member What are the main considerations for boosting immunization?
What are the main considerations for boosting immunization? What are the main considerations for the third booster vaccination of the new crown vaccine? On July 29, Lu Xuexin, an expert from the Institute for Viral Disease Control and Prevention of the Chinese Center for Disease Control and Prevention, said in an interview with The Paper that the first is safety, the second is effectiveness, and then the availability of vaccines
It is worth mentioning that China's safety and effectiveness study on the third dose of the new crown vaccine has also been published, which provides data support for the next vaccination strategy
Recently, Kexing published a new coronary inactivated vaccine phase II clinical trial result on Medrxiv, a health science preprint paper platform, showed that although the level of neutralizing antibody decreased after 6 months, the two-dose vaccine immunization program produced good immunity Memory, after the third dose of vaccination, it can quickly induce a strong immune response, and the neutralizing antibody titer is significantly increased.
In the discussion section, the author stated that although the third dose of vaccination may be necessary, the formulation and implementation of the strengthening plan should take into account the local epidemic situation, infection risk, vaccine supply and other relevant factors
Lu Xuexin believes that the data released by Kexing also show that the safety of the third dose of vaccination and the titers of neutralizing antibodies are both good.
Who gets the third shot?
Who gets the third shot? If the 6-month protection period is used as the limit, some people have already received the second dose of the inactivated new crown vaccine for 6 months
So, should everyone get the third shot? What are the considerations?
"If the third needle is really implemented, based on the urgency and risk assessment, front-line personnel, immigration-related personnel, high-risk industry practitioners and public service personnel should belong to the first echelon
.
" Lu Xuexin said
.
Jin Dongyan also believes that some high-risk groups such as medical staff, airport staff, and elderly care workers need to be vaccinated as soon as possible to raise the level of neutralizing antibodies.
There are only benefits and no harm
.
Whether the person who received the third shot needs to check the antibody level before deciding whether to vaccinate or not
.
"The new crown antibody test should become a routine operation, and it is reasonable
.
" Jin Dongyan believes that it is a pity that the current antibody test has not played much use
.
What vaccine should I get for the third shot?
What vaccine should I get for the third shot? Concerns about the protective effect of the new crown vaccine also stem from the mutation of the new crown virus.
The delta mutant virus has led to a decline in the protection rate of the vaccine has become a fact that must be faced
.
According to Israel’s Ynet news network on July 5, the latest data from the Israeli Ministry of Health show that from June 6 to early July, more people who have been vaccinated with Pfizer were infected with the virus.
The effectiveness of Pfizer’s vaccine against infection has been since June this year.
The former 94.
3% has dropped to 64% today, but the infected people who have been vaccinated have only mild symptoms
.
The data published by Kexing shows that the third dose of its new crown inactivated vaccine greatly increases the immune response, and the neutralizing antibody titer is several times higher than that after two doses.
However, whether the mutant strain has the same effect remains to be studied
.
Regarding the delta mutant strain of the new coronavirus that is currently spreading around the world, whether China's third inactivated new crown vaccine can be added with the inactivated delta mutant strain, experts also responded to this in an interview with The Paper
.
"The third shot of the vaccine needs to add the inactivated Delta strain.
It seems very simple.
It is still very difficult to actually make this new vaccine
.
" Lu Xuexin told The Paper, because it involves the management regulations and regulations of biological drugs.
There are many aspects such as safety and effectiveness.
This process involves multiple links such as strain cultivation and screening, vaccine production technology, clinical trials, regulatory approvals, and so on.
It also needs to consider factors such as virus mutation rate and timeliness of inoculation
.
"Replacement of the virus strain is not an emergency, and it cannot be done
.
" Jin Dongyan also said that in the long run, the virus strain should be updated, but there is currently no unified international decision on whether or not to replace the virus strain
.
Jin Dongyan believes that the virus is now in a race against human immunity.
Alpha strain was still prevalent before, but now it has become a Delta strain.
Maybe when a vaccine for a new strain is made, other strains will begin to spread
.
"What we need to consider now is to get the third shot, just get the existing vaccine
.
" Jin Dongyan said that research shows that "mixed fighting" can better stimulate the human immune response
.
If conditions permit, vaccines of different technical routes can be selected for the third shot, such as recombinant new crown vaccine or Fubitai (mRNA vaccine) for previously inactivated vaccines
.
Focus on the new crown pneumonia epidemic
This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only.
This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of
the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed
description of the concern or complaint, to
service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content
will be removed immediately.
