Exp Neurol: New study could help treat stroke.

August 20, 2020 /--- stroke is currently one of the leading causes of long-term disability in the United States.
stroke can cause paralysis on one side of the body and can cause speech, vision problems and memory loss.
recently, researchers at the UConn School of Medicine published a paper in the journal Alec Neurology that found the molecules that successfully inhibit stroke and recovery from injury after stroke.
stroke occurs when the artery in the brain is blocked (Photo: www.pixabay.com), which accounts for 87 percent of all stroke cases.
the amount of blood and oxygen entering the brain is greatly reduced, leading to damage or death of brain cells.
or dying brain cells release excess ATP, causing their subject P2X4 (P2X4R) to be overstulged.
when P2X4R is overactive, it causes a series of harmful effects in brain cells, leading to isoemia brain damage.
study, researchers found that inhibiting P2X4R regulates the activity of an immune cell that plays an important role in an inflammatory response to stroke.
by blocking the activity of the subject, the researchers found that excessive immune responses were effectively suppressed to improve the recovery of acute and chronic strokes.
using mouse models, the researchers observed improved balance and coordination after intervention and reduced anxiety.
further, the authors found that P2X4R inhibitor therapy reduced the total number of leaching white blood cells, which are white blood cells that, over time, promote ischemia damage.
treatment effectively reduced the surface expression and activation of P2X4R cells in brain tissue after stroke injury without reducing their total protein levels.
the technology will have a significant impact because there are currently no effective drugs on the market for stroke damage, except for a few narrow, soluble blood clots or methods for removing blood clots.
(bioon.com) Source: New mechanism for stroke treatment show proof-of-concept Source: Pranay Srivastava et al. Neuroprotective and neuro-rehabilitative effects of acute prgic receptor P2X4 (P2X4R) blockade after ischemic stroke, Neurology (2020). DOI: 10.1016/j.expneurol.2020.113308.