Exercise not only prevents cancer, but also helps patients receiving ADT suppress prostate cancer!

Sports oncology, the application of sports medicine in cancer, has developed rapidly in the field of clinical oncology and has provided a solid foundation for cancer patients to perform physical activities or exercises
.

A number of studies have shown that there is a negative correlation between physical activity and disease progression and cancer-specific mortality in patients, including patients with prostate cancer

Sports oncology, the application of sports medicine in cancer, has developed rapidly in the field of clinical oncology and has provided a solid foundation for cancer patients to perform physical activities or exercises

ADT is an effective treatment to prevent the growth of prostate cancer and is a common treatment for patients with prostate cancer

The purpose of this exploratory study is to investigate the effect of 12-week exercise-based intervention on serum myokine levels in prostate cancer patients undergoing ADT , and to examine the cancer-suppressive effect of exercise-conditioned serum
.

The purpose of this exploratory study is to investigate the effect of 12-week exercise-based intervention on serum myokine levels in prostate cancer patients undergoing ADT , and to examine the cancer-suppressive effect of exercise-conditioned serum
.

Myocyte factor

1.
Body composition and strength

1.
Body composition and strength 1.
Body composition and strength

The average age of the patients was 73.
3±5.
6 years, and the average age of ADT was 21.
2±15.
9 months
.

All patients had Gleason score ≥ 7 , 4 of them reported lung or lymph node metastasis

The average age of the patients was 73.

After 12 weeks of training, leg lift (Δleg compression = +25.

After 12 weeks of intervention, the relative strength also increased significantly

2.
Serum myocyte factor , IGF-1 and IGFBP-3 levels

2, serum muscle cell factor , IGF-1 and IGFBP-3 levels 2, 2,serum muscle cell factor , IGF-1 and IGFBP-3 levelsmyocyte factor

The serum concentrations of 6 different myocytokines (SPARC, OSM, decorin, IL-6, IL-15 and irisin) and IGF-1 and IGFBP-3 were analyzed from baseline and post-intervention serum
.

Serum OSM level (ΔOSM = + 4.

The serum concentrations of 6 different myocytokines (SPARC, OSM, decorin, IL-6, IL-15 and irisin) and IGF-1 and IGFBP-3 were analyzed from baseline and post-intervention serum

3.
Growth of prostate cancer cells

3.
Growth of prostate cancer cells 3.
Growth of prostate cancer cells

The Cell Index is recorded every 15 minutes, and Figure 4 shows the time-course changes of the Cell Index every hour
.

After adding the patient's serum before and after exercise intervention, the cell growth showed a similar special pattern during the first 24 hours of culture (Period (a) in Figure 4A)

The Cell Index is recorded every 15 minutes, and Figure 4 shows the time-course changes of the Cell Index every hour

Overall, the 72-hour average cell index decreased by 21.
3% (baseline: 5.
829±1.
112; intervention: 4.
566±1.
515, p = 0.
012)
.
The 72h average cell growth rate was significantly reduced by 22.
5% (baseline: 0.
080±0.
016; after intervention: 0.
062±0.
021, p=0.
012) (Figure 4C)
.
This reduction in cell growth was particularly pronounced after 25 hours of culture (Figure 4A and D), and became significantly different after 45 hours (Figure 4A)
.

This study provides evidence for the enhanced expression of myocytes in serum and the resulting tumor suppressive effect in patients with prostate cancer after short-term exercise-based intervention
.
Importantly, myocyte factor expression is correlated with relative changes in lean body mass, emphasizing the importance of maintaining or increasing muscle mass in these patients
.
Future randomized controlled trials need to further clarify the effect of exercise on the expression of muscle cytokines, especially the details of exercise prescription, such as threshold exercise intensity, volume, and optimized pattern of muscle cytokine expression
.
Although this study has proved that the long-term effects of exercise are very beneficial, in cancer patients receiving different treatments, the acute response of a single (dose) exercise and the impact on cancer biology need to be explored
.
In the future, we also need to study the human serum and intercellular mechanisms under both acute and chronic exercise conditions to clarify the direct tumor-inhibiting effect of muscle cytokines in the treatment of prostate cancer patients with ADT
.

This study provides evidence for the enhanced expression of myocytes in serum and the resulting tumor suppressive effect in patients with prostate cancer after short-term exercise-based intervention
.
Importantly, myocyte factor expression is correlated with relative changes in lean body mass, emphasizing the importance of maintaining or increasing muscle mass in these patients
.
Myocytokine expression is correlated with relative changes in lean body mass, emphasizing the importance of maintaining or increasing muscle mass in these patients
.
Future randomized controlled trials need to further clarify the effect of exercise on the expression of muscle cytokines, especially the details of exercise prescription, such as threshold exercise intensity, volume, and optimized pattern of muscle cytokine expression
.
Although this study has proved that the long-term effects of exercise are very beneficial, in cancer patients receiving different treatments, the acute response of a single (dose) exercise and the impact on cancer biology still need to be explored
.
In the future, we also need to study the human serum and intercellular mechanisms under both acute and chronic exercise conditions to clarify the direct tumor-inhibiting effect of muscle cytokines in the treatment of prostate cancer patients with ADT
.

Original source:

Original source:

Jin-Soo Kim, et al.
Myokine Expression and Tumor-suppressive Effect of Serum following 12 Weeks of Exercise in Prostate Cancer Patients on ADT.
Medicine & Science in Sports & Exercise:  October 2021-Volume 53-Issue 10-p 2054-2065

Jin-Soo Kim, et al.
Myokine Expression and Tumor-suppressive Effect of Serum following 12 Weeks of Exercise in Prostate Cancer Patients on ADT.
October 2021-Volume 53-Issue 10-p 2054-2065 October 2021-Volume 53-Issue 10 -p 2054-2065 leave a message here