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Gliomas are the most common malignant primary brain tumors
Gliomas are the most common malignant primary brain tumors
ATRX gene mutation (loss of ATRX protein expression, ATRX-) is associated with activation of the alternative telomere extension (ALT) pathway, which is one of the important pathways for maintaining tumor cell immortality, and the identification of ATRX- status in IDH+ glioma can further Guide specific classification and diagnosis, and can more accurately predict prognosis and individualize treatment
However, genotype assessment relies on invasive methods such as surgical resection and biopsy , and considerable spatial and temporal heterogeneity inevitably reduces sampling accuracy .
However, since radiomics includes a wealth of useful quantitative information, it will be challenging to compare all selected radiomics signatures between subjects or patients
A study published in European Radiology presents a nomogram for predicting IDH and ATRX mutation status in LrGG patients, providing clinicians with an easy-to-use and noninvasive stratification of IDH and ATRX mutation status in LrGG patients.
A total of 111 LrGG patients (76 IDH mutant and 35 IDH wild type) were included in this study, divided into training set (n = 78) and validation set (n = 33) for prediction of IDH mutation .
Radiomics nomogram enables identification of IDH -mutated (C-index: training set=0.
In conclusion, a nomogram combining age, gender, and radiomic features provides a non-invasive imaging method for predicting IDH and ATRX mutations in LrGG patients, which can assist in the development of personalized treatment plans
Original source:
Original source:Shiman Wu, Xi Zhang, Wenting Rui, et al.
Shiman Wu, Xi Zhang, Wenting Rui, et al.
A nomogram strategy for identifying the subclassification of IDH mutation and ATRX expression loss in lower-grade gliomas .
DOI: 10.
1007/s00330-021-08444-1 A nomogram strategy for identifying the subclassification of IDH mutation and ATRX expression loss in lower-grade gliomas 10.
1007/s00330-021-08444-1
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