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Recently, ACRG (Asian Cancer Research Group) willGastric cancer (GC) is divided into four distinct molecular subtypes : (1) tumors with microsatellite instability (MSI); (2) microsatellite stable (MSS) tumors with p53 signature (CDKN1A and MDM2 expression); (3) MSS tumors without p53 signature; (4) MSS tumors with epithelial-mesenchymal transition (EMT) phenotype
Recently, ACRG (Asian Cancer Research Group) willGastric cancer (GC) is divided into four distinct molecular subtypesGastric cancer : (1) tumors with microsatellite instability (MSI); (2) microsatellite stable (MSS) tumors with p53 signature (CDKN1A and MDM2 expression); (3) MSS tumors without p53 signature; (4) ) MSS tumors with epithelial-mesenchymal transition (EMT) phenotype
Despite the clinical importance of molecular subtypes, gene expression profiling tests are expensive and cannot be performed as a routine screening program for GC patients .
A study published in the journal European Radiology established a predictive model of EMT subtypes including CT images and a nomogram incorporating known clinicopathological variables to enable patient personalization .
This study analyzed CT images and molecular subgroups (n = 451) of patients undergoing gastric cancer (GC) resection .
Based on transcriptome analysis, a total of 88 patients with EMT subtype and 363 patients with non-EMT subtype were evaluated .
Figure ROC curve of EMT molecular subtype gastric cancer prediction model and ROC curve of 1000 bootstrap samples .
Figure ROC curve of EMT molecular subtype gastric cancer prediction model and ROC curve of 1000 bootstrap samples .
This study shows that a predictive model for predicting the molecular subtype GC of EMT can be established using the patient's age, Lauren classification and gastric wall conditions on CT , which can be used as a very valuable screening tool and realize the identification of EMT subtypes.
Original source :
Dong Ik Cha , Jeeyun Lee , Woo Kyoung Jeong , et al .
Dong Ik Cha Jeeyun Lee Woo Kyoung Jeong ,et al 10.
1007/s00330-021-08094-3 10.
1007/s00330-021-08094-3Leave
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