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European Radiology: Evaluation of left atrial remodeling in patients with breast cancer treated with adjuvant trastuzumab by CMRI

 Last Update: 2022-04-15
 Source: Internet
 Author: User

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For patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer , anti -HER2 therapies such as trastuzumab have greatly improved survival in both adjuvant and metastatic settings .

Cardiac magnetic resonance imaging (CMR) is the gold standard technique for quantitative assessment of cardiac chambers , with higher reproducibility and spatial resolution than echocardiography

In this prospective, two-center longitudinal study, 41 women with HER2-positive breast cancer received 12 months of adjuvant trastuzumab in addition to standard chemotherapy

Among 41 women (mean age, 52 ± 11 [SD] years; 56% received anthracyclines), one patient developed trastuzumab-induced cardiotoxicity (TIC), which resulted in trastuzumab interrupted for one cycle

In this prospective cohort study of trastuzumab-treated breast cancer patients, there was a small but significant subclinical decrease in LAEF and a modest increase in LAmin after initiation of treatment , which returned to baseline 6 months after treatment was discontinued

Original source :

Flora Huang , Christine Brezden-Masley , Kelvin KW Chan , et al .

Flora Huang Christine Brezden-Masley Kelvin KW Chan , et al Evaluation of left atrial remodeling using cardiovascular magnetic resonance imaging in breast cancer patients treated with adjuvant trastuzumab 10.
1007/s00330-021-08466-9 10.
1007/s00330-021-08466-9

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