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Eur Urol Focus: Chromosomal instability of cell-free DNA can serve as a prognostic biomarker for androgen deprivation in the treatment of metastatic hormone-sensitive prostate cancer

 Last Update: 2022-10-12
 Source: Internet
 Author: User

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Although patients with metastatic hormone-sensitive prostate cancer (mHSPC) can be treated with androgen deprivation therapy (ADT), metastases can still progress to anti-prostate cancer (mCRPC

Recently, researchers from South Korea published an article in Eur Urol Focus investigating the role

This prospective study included 75 patients with elevated prostate-specific antigens, analyzed their cell-free DNA (cfDNA) in pre-treatment plasma samples, and performed low-depth whole-genome sequencing of cfDNA to identify CNAs

Of the 22 IScore-positive patients, 86.

Different factors predict the development of castration resistance

Taken together, IScore can serve as a biomarker

Original Source:

Chung Un Lee， Eunhae Cho， Junnam Lee et al.

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