Eur Urol: Cancer control outcomes after local therapy with high-intensity focused ultrasound in patients with non-metastatic prostate cancer

Treatment options for patients with non-metastatic, clinically significant prostate cancer include radical prostatectomy and radical radiation therapy
.

In intermediate-risk and high-risk patients, curative therapy improves progression-free and cancer-specific survival, but also brings some treatment-related complications, including genitourinary and rectal side effects

Radical therapy improves progression-free survival and cancer-specific survival in intermediate- and high-risk patients, but also carries some treatment-related complications, including genitourinary and rectal side effects at intermediate risk and high-risk patients, curative therapy improves progression-free survival and cancer-specific survival, but also brings some treatment-related complications, including genitourinary and rectal side effects

The goal of local therapy is to treat an area of ​​cancer to achieve tumor control while reducing the functional impairment associated with the treatment
.

Recently, researchers from the United Kingdom published an article in the journal Eur Urol reporting oncological outcomes and adverse events after high-intensity focused ultrasound (HIFU) treatment of non-metastatic prostate cancer
.

reported oncological outcomes and adverse events following high-intensity focused ultrasound (HIFU) for non-metastatic prostate cancer

The researchers analysed recorded data from 1379 follow-up patients from 13 centres in the UK (2005-2020)
.

Of these, 325 (24%) patients were followed for 5 years or longer

1379 325

The median (interquartile range) age of the study population was 66 (60-71) years, PSA was 6.
9 (4.
9-9.
4) ng/mL, and 65% (896/1379) were D'Amico Moderate risk, 28% (386/1379) were high risk
.

The overall median follow-up was 32 (17-58) months; for those with ≥5 years of follow-up, the median follow-up was 82 (72-94) months

82

Kaplan-Meier curve of FFS

Kaplan-Meier curve of FFS

In conclusion, among selected patients with clinically significant prostate cancer, 6 out of 10 and 3 out of 10 had intermediate-risk and high-risk cancers, respectively, and had good cancer control during the interim treatment period

Among selected patients with clinically significant prostate cancer, 6 and 3 out of 10 were intermediate-risk and high-risk cancer patients, respectively, and had good cancer control in selected clinically significant prostate cancer during the interim treatment period 6 in 10 and 3 out of 10 patients with cancer have intermediate-risk and high-risk cancers, respectively, and have good cancer control over the interim period of treatment

 

Original source:

Original source:

Deepika Reddy, Max Peters, Taimur T Shah et al.

Cancer Control Outcomes Following Focal Therapy Using High-intensity Focused Ultrasound in 1379 Men with Nonmetastatic Prostate Cancer: A Multi-institute 15-year Experience

 

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