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Eur Urol: B7-H3 can be used as a therapeutic target for advanced prostate cancer

 Last Update: 2022-09-30
 Source: Internet
 Author: User

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B7-H3 is a cell surface immunomodulatory glycoprotein
that is overexpressed in prostate cancer (PC).

Recently, researchers from the United Kingdom published an article in Eur Urol investigating the expression of B7-H3 in hormone-sensitive (HSPC) and castration-resistant (CRPC) PC biopsy tissues in the same patient and linked
to PC genomics.

The researchers performed immunohistochemistry and next-generation sequencing of 98 clinically annotated CRPC living tissues, including 72 patients who
also had HSPC living tissue.

The study found that B7-H3 is one of
the most highly expressed immunomodulatory genes in CRPCs.

Anti-tumor activity of anti-B7-H3 ADCs in human CRPC models

Taken together, B7-H3 is often overexpressed in CRPC compared to normal tissues and other members of the B7 family, meaning it may be a highly probable therapeutic target for these diseases
.

Original Source:

Christina Guo， Ines Figueiredo， Bora Gurel et al.

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