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Eur Urol: Association between age, prostate cancer risk and higher Gleason score in a long-term screening program

 Last Update: 2022-03-05
 Source: Internet
 Author: User

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It is well known that age is a risk factor for the development of prostate cancer (PC)
.

The most important prognostic variable, the Gleason score (GS), was also associated with age at diagnosis

Diagnostic Screening

Previous studies have suggested a possible association between older age, increased risk of prostate cancer (PC), and higher Gleason scores
.

Recently, researchers from Sweden, published in Eur Urol , investigated these associations in the Göteborg-1 randomized, population-based PC screening trial

Possible association between increased risk of prostate cancer (PC) and higher Gleason score Possible association between increased risk of prostate cancer (PC) and higher Gleason score The associations were investigated in the screening trial The Göteborg-1 randomized, population-based PC screening trial

G? The cohort of the teborg-1 screening trial consisted of 10,000 men (aged 50-64 years) randomly selected from the Gothenburg region of Sweden
.

Between 1995 and 2014, they had a prostate-specific antigen (PSA) test every two years with an upper age limit of 70 years (range 67-71 years)

Overall, 7625 men had at least one PSA test and 1022 men were diagnosed with PC
.

For men screened for PC, age was associated with greater risk of clinically significant PC than round of screening and year of detection (P < 0.

among men diagnosed with prostate cancer

In conclusion, the increased risk of older men with higher Gleason scores should be considered when counseling men for the early diagnosis and treatment of PC

The increased risk of higher Gleason score in older men should be considered when counseling men for the early diagnosis and treatment of PC

Original source:

Rebecka Arnsrud Godtman, Karin Stinesen Kollberg, Carl-Gustaf Pihl et al.

The Association Between Age, Prostate Cancer Risk, and Higher Gleason Score in a Long-term Screening Program: Results from the G ö teborg-1 Prostate Cancer Screening Trial ö

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