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Osteosarcoma (OS) is the most common primary malignant bone tumor, with the highest incidence in children and adolescents.
Osteosarcoma (OS) is the most common primary malignant bone tumor with the highest incidence in children and adolescents.
In osteosarcoma, chemotherapy-induced tumor necrosis is a recognized prognostic predictor.
Magnetic resonance imaging (MRI) has become an important method for the diagnosis of primary bone tumors and the detection of postoperative tumor recurrence.
Recently, a study published in the journal European Radiology evaluated the parameters of diffusion-weighted imaging (DWI) and dynamic enhanced magnetic resonance imaging (DCE-MRI) of the tumor and the surrounding area of OS patients, which are the tumor histology of neoadjuvant chemotherapy before surgery.
Methods of evaluating patients with osteosarcoma: This study included 34 patients with OS.
Methods of evaluating patients with osteosarcoma: This study included 34 patients with OS.
In the tumor area, there is moderate evidence that responders have lower post-Ktrans than poor responders (p = 0.
Figure 1 A ROC curve of tumor and peritumoral area parameters.
Figure 1 A ROC curve of tumor and peritumoral area parameters.
Figure 2 Event-free survival curves of subgroups stratified according to the median value of (a) post-Kt in the tumor area and (b) pre-Ve in the surrounding area of the tumor.
Figure 2 Event-free survival curves of subgroups stratified according to the median value of (a) post-Kt in the tumor area and (b) pre-Ve in the surrounding area of the tumor.
Figure 3 Stratification according to the median value of (a)post-Kt, (b)pre-Ve in the tumor area and (c)pre-Ve, (d)post-Ve, (e)post-ADC in the surrounding area of the tumor Survival curve of the subgroup.
Figure 3 Stratification according to the median value of (a)post-Kt, (b)pre-Ve in the tumor area and (c)pre-Ve, (d)post-Ve, (e)post-ADC in the surrounding area of the tumor Survival curve of the subgroup.
The DWI and DCE-MRI parameters of the tumor and peritumoral area can reflect the chemotherapy response and predict EFS and overall survival rate.
Original source: Original source:
Yuewen Hao,Rui An,Yingsen Xue,et al.
Yuewen Hao,Rui An,Yingsen Xue,et al.
Prognostic value of tumoral and peritumoral magnetic resonance parameters in osteosarcoma patients for monitoring chemotherapy response.
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