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Eur Radiol: How to evaluate the efficacy of sorafenib for advanced liver cancer?

 Last Update: 2021-03-19
 Source: Internet
 Author: User

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Hepatocellular carcinoma (HCC) is the sixth most common malignant tumor in the world and the fourth leading cause of cancer-related deaths.

Hepatocellular Carcinoma Hepatocellular Carcinoma (HCC) is the sixth most common malignant tumor in the world and the fourth leading cause of cancer-related deaths.

Sorafenib-induced liver damage mainly develops into specific hepatotoxic damage.

MRE (Magnetic resonance elastography, MRE) is a non-invasive assessment of liver stiffness (LS) method based on quantitative imaging a magnetic resonance imaging (Magnetic resonance imaging, MRI) of.

Recently, a study published in the journal European Radiology explored the clinical significance of LS quantified by MRE in patients with advanced HCC treated with sorafenib, and analyzed whether LS before sorafenib administration can be used as a predictor of OS or not.

According to the inclusion and exclusion criteria, this study selected 50 patients with advanced HCC treated with sorafenib from a cohort of prospectively maintained chronic liver disease patients.

High MRE quantified LS as continuous (per kPa, hazard ratio (HR) 1.

Figure 1 Kaplan-Meier analysis of progression-free survival (PFS).

Figure 2 The correlation between liver stiffness (LS) quantified by magnetic resonance elastography (MRE) and clinical variables (a albumin and b total bilirubin)

This study confirmed that LS quantified by MRE can be used to predict the prognosis of patients with advanced HCC treated with sorafenib.

Original source: Original source:

Bohyun Kim, Soon Sun Kim, Sung Won Cho, et al.

Bohyun Kim,Soon Sun Kim,Sung Won Cho,et al.
Liver stiffness in magnetic resonance elastography is prognostic for sorafenib-treated advanced hepatocellular carcinoma.
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1007/s00330-020-07357-9 Bohyun Kim,Soon Sun Kim,Sung Won .
CHO, et Al Liver Stiffness in Magnetic Resonance elastography IS-Treated sorafenib prognostic for advanced hepatocellular carcinoma.
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