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    Home > Active Ingredient News > Antitumor Therapy > Eur J Cancer: Long-term outcome of patients with advanced melanoma treated with pembrolizumab

    Eur J Cancer: Long-term outcome of patients with advanced melanoma treated with pembrolizumab

    • Last Update: 2021-10-10
    • Source: Internet
    • Author: User
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    Although education and awareness of the risk factors of melanoma have been improved in today's society, the number of newly diagnosed cases each year continues to increase


    immunity

    However, the prognosis of early stable melanoma patients treated with pembrolizumab is still unclear


    Patients who participated in the KEYNOTE-001 and KEYNOTE-006 studies and were stable or had partial/complete remission at the 12th or 24th week were included


    Survival analysis based on 12-week treatment response group

    Survival analysis based on 12-week treatment response group

    Of the 294 patients included in the 12th week analysis, 107 were in stable condition, of which 7 (6.


    The overall survival (OS) rates at 48 months for patients with complete remission, partial remission and stable disease at week 12 were 95.


    Survival analysis based on 24-week treatment response groups

    Survival analysis based on 24-week treatment response groups

    At the 24th week of the analysis, similar results were observed in 241 patients


    The 48-month OS rate of patients with stable disease and subsequent remission at the 12th week was 72.


    Analysis based on changes in comprehensive treatment response

    Analysis based on changes in comprehensive treatment response

    In summary, most patients with stable melanoma in the early stage (12 weeks) treated with pembrolizumab can obtain partial or complete remission afterwards


    Most early (12 weeks) stable melanoma patients treated with pembrolizumab can later obtain partial or complete remission.


    Original source:

    Hamid Omid,Robert Caroline,Daud Adil et al.


    Long-term outcomes in patients with advanced melanoma who had initial stable disease with pembrolizumab in KEYNOTE-001 and KEYNOTE-006

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