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Eur Arch Otorhinolaryngol: Long-term Hearing Follow-up of Pediatric Platinum-Induced Ototoxicity

 Last Update: 2022-03-04
 Source: Internet
 Author: User

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The platinum drugs cisplatin and carboplatin are widely used to treat several childhood and adolescent malignancies, including neuroblastoma, osteosarcoma, germ cell tumor, teratoma, hepatoblastoma, and various brain tumors (gliomas).
, astrocytoma, medulloblastoma)
.

Irreversible bilateral sensorineural hearing loss is a common side effect of platinum compounds
.

Long-term hearing monitoring and management of hearing impairment are emerging concerns in pediatric oncology due to improved overall survival

Researchers from Italy, published in Eur Arch Otorhinolaryngol, conducted long-term hearing follow-up of pediatric platinum-induced ototoxicity Hearing follow-up

The study was a retrospective observational design
.

Between 2007 and 2014, 38 of the 116 children who received chemotherapy (cisplatin and/or carboplatin) and/or radiation at the investigator's institution were recruited

At the end of the 5-year follow-up, there was a significant increase in ototoxicity compared with that observed at the end of chemotherapy (52.
5% vs 39.
5%, P<0.
001)
.

Late-onset hearing loss occurred in 13.

Distribution of hearing loss at end of follow-up

In conclusion, long-term monitoring of at least 5 years may prevent the deleterious effects of hearing deprivation following platinum-based chemotherapy in children

Long-term monitoring for at least 5 years can prevent harmful effects of hearing deprivation after platinum-based chemotherapy in children Long-term monitoring for at least 5 years can prevent harmful effects of hearing deprivation after platinum-based chemotherapy in children

Original source:

Original Source: Original Source:

Anna Rita Fetoni, Francesca Brigato, Eugenio De Corso et al.

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