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ESMO Open: Tumor mutation burden can predict the prognosis of patients with oral squamous cell carcinoma

 Last Update: 2021-06-21
 Source: Internet
 Author: User

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The oral cavity is the most common site of head and neck squamous cell carcinomas (HNSCCs)
.

Most patients are already at an advanced stage when they are diagnosed, and combined treatment is often used, of which surgery is the main treatment measure

To explore the molecular profile of oral squamous cell carcinoma (OCSCC), and to evaluate the tumor mutational burden (TMB) and the prognostic significance of classical molecular and clinical parameters

Enrolled 151 OCSCC patients who underwent preoperative treatment at Institut Curie
.

The internal targeted next-generation sequencing panel (571 genes) was used to sequence tumor DNA from frozen samples

Mutation profile of OCSCC patients

Tumor pathological staging, extra-lymph node spread, vascular cancer plug and peripheral nerve infiltration are all related to DFS and OS
.

TP53 is the most commonly mutated gene (71%)

Tumor staging, extranodal diffusion, vascular cancer invasion plug and peripheral nervous DFS and OS were associated with vascular

Correlation between tumor mutation burden and patients' DFS and OS

In univariate and multivariate analysis, changes in the transforming growth factor-β pathway (4%) were associated with poor OS (P=0.
01) and DFS (P=0.
02)
.

High TMB values are associated with prolonged OS (P values corresponding to the highest 10% and 20% TMB values are 0.

High TMB value and prolonged OS-related tumor pathological staging combined with high TMB value are associated with good prognosis

In summary, the results of this study show that high TMB values are associated with a good prognosis for OCSCC patients undergoing preoperative treatment

High TMB value is correlated with good prognosis of OCSCC patients undergoing preoperative treatment High TMB value is correlated with good prognosis of OCSCC patients undergoing preoperative surgery

Original source:

Moreira A,Poulet A,Masliah-Planchon J et al.

Prognostic value of tumor mutational burden in patients with oral cavity squamous cell carcinoma treated with upfront surgery in this message

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