Epidemiological investigation found new changes in measles incidence in adults in mobile populations

the Department of Epidemiology and Research of the Department of Medical Prevention of the Fourth Military Medical University recently completed the "MeaslesdiseasePrevention Epidemiological Survey of China's mobile population" research found that in China's mobile population, adult measles incidence has appeared some new changes, that is, the incidence of mobile population is higher than the urban population, showing the incidence of concentrated, long fever time, High Positive Rate of IgM antibody, complications and so onIn this regard, experts put forward the "three strengthening" social preventive measuresMeasles is an acute respiratory transinfection caused by the measles virus, with fever, conjunctivitis, upper respiratory inflammation, oral mucosa spots and peripheral papules as the main manifestations, which can cause pneumonia, laryngitis and encephalitis and other serious diseasesSince the 1960s, China has carried out a wide range ofchildrenmeasles vaccination, the incidence of the disease has decreased significantly, the intensity of the national widespread epidemic has been basically controlledBut in recent years, measles has "re-emerged" in some adolescents and adults due to frequent population movements and a decline in antibody drops in the populationIn order to grasp the prevalence and law of measles in the mobile population of Our country, researchers of the Fourth Military Medical University were infectedthe hospital, the fourth military medical university Tangduhospitaland the first affiliatedhospital of Xi'an Jiaotong Universityconducted an investigationUsing retrospective analysis, they collected 118 cases of adult measles patients admitted to these three hospitals from 2005 to 2006, and analyzed and compared their ethos, blood routine, liver function and measles IgM antibody testing in accordance with epidemiological standards, and clinical characteristics The results show that the incidence of measles in adults in mobile population is higher than that of xi'an population, and the incidence time is more concentrated Of the 118 patients, 67 cases, or 56.7%, were foreign mobile, and 51 were in Xi'an, accounting for 43.1% In the patient's onset time, April to May was the most concentrated, with a total of 86 cases, accounting for 74.6% of the total All but six of these patients have a clear history of measles vaccination, the rest are unknown The clinical characteristics of patients are long heat stroke and high thermal peak All patients developed fever, 97 cases of body temperature above 39 degrees, the average number of days of fever 8.04 days, the longest 16 days The patient had a high positive rate of measles IgM antibody Serum tested 114 cases positive, the positive rate reached 96.6% The study also found that these patients had more measles complications Among them, there were 17 cases of acute tracheotomy, 5 cases of bronchopneumonia and 37 cases of measles viral hepatitis These epidemiological changes have serious effects and harms on the treatment and rehabilitation of patients According to Professor Yu Yongping, who was involved in the study, the main reasons for the "resurgence" of measles in adults are due to the fact that the number of mobile populations is from rural areas, and because of the limited technical conditions for local measles vaccination, leakage has led many people to fail to get effective immunization in the of infants ; There is a problem of recessive infection in the vaccine population, i.e over time, some people's antibody levels gradually decline and susceptibility increases, and third, the genetic variation of the wild type of measles virus may be mutated, which may cause antigen changes, thereby weakening the protection of existing measles vaccines, leading to measles epidemic in adults To this end, the researchers stressed the need to do a good job of "three strengthening" prevention and control work: first, to strengthen the guidance of planned immunization, especially to do a good job of adult follow-up strengthening immunization work; (Wu Yifu)